Author | Aimbire, F. | |
Author | Santos, F. V. | |
Author | Albertini, R. | |
Author | Faria Neto, Hugo Caire C. | |
Author | Mittmann, J. | |
Author | Soares, C. Pacheco | |
Access date | 2020-02-13T17:03:55Z | |
Available date | 2020-02-13T17:03:55Z | |
Document date | 2008 | |
Citation | AIMBIRE, F. et al. Low-level laser therapy decreases levels of lung neutrophils anti-apoptotic factors by a NF-κB dependent mechanism. International Immunopharmacology, v. 8, p. 603-605, 2008. | pt_BR |
ISSN | 1567-5769 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/39931 | |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Rights | restricted access | pt_BR |
Title | Low-level laser therapy decreases levels of lung neutrophils anti-apoptotic factors by a NF-kappaB dependent mechanism | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/j.intimp.2007.12.007 | |
Abstract | Background and objective: Low-level laser therapy (LLLT) is a known modulator of inflammatory
process. Herein we studied the effect of 660 nm diode laser on mRNA levels of neutrophils
anti-apoptotic factors in lipopolysaccharide (LPS)-induced lung inflammation. Study design/
methodology: Mice were divided into 8 groups (n=7 for each group) and irradiated with energy
dosage of 7.5 J/cm2. The Bcl-xL and A1 mRNA levels in neutrophils were evaluated by Real Time-
PCR (RT-PCR). The animals were irradiated after exposure time of LPS. Results: LLLT and an
inhibitor of NF-κB nuclear translocation (BMS 205820) attenuated the mRNA levels of Bcl-xL
and A1 mRNA in lung neutrophils obtained from mice subjected to LPS-induced inflammation.
Conclusion: LLLT reduced the levels of anti-apoptotic factors in LPS inflamed mice lung neutrophils
by an action mechanism in which the NF-κB seems to be involved. | pt_BR |
Affilliation | Universidade do Vale do Paraíba. Instituto de Pesquisa e Desenvolvimento. São José dos Campos, SP, Brasil. | pt_BR |
Affilliation | Universidade do Vale do Paraíba. Instituto de Pesquisa e Desenvolvimento. São José dos Campos, SP, Brasil. | pt_BR |
Affilliation | Universidade do Vale do Paraíba. Instituto de Pesquisa e Desenvolvimento. São José dos Campos, SP, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade do Vale do Paraíba. Instituto de Pesquisa e Desenvolvimento. São José dos Campos, SP, Brasil. | pt_BR |
Affilliation | Universidade do Vale do Paraíba. Instituto de Pesquisa e Desenvolvimento. São José dos Campos, SP, Brasil. | pt_BR |
Subject | Neutrófilos pulmonares | pt_BR |
Subject | Terapia a laser de baixo nível | pt_BR |
Subject | Fatores anti-apoptóticos | pt_BR |
Subject | NF-κB | pt_BR |
Subject in Spanish | Low-level laser therapy | pt_BR |
Subject in Spanish | Anti-apoptotic factors | pt_BR |
Subject in Spanish | Lung neutrophils | pt_BR |
Subject in Spanish | NF-κB | pt_BR |
e-ISSN | 1878-1705 | |
Embargo date | 2025-01-01 | |