Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/40020
Title: The 2019-new coronavirus epidemic: Evidence for virus evolution
Authors: Benvenuto, Domenico
Giovanetti, Marta
Ciccozzi, Alessandra
Spoto, Silvia
Angeletti, Silvia
Ciccozzi, Massimo
Affilliation: University Campus Bio‐Medico of Rome. Unit of Medical Statistics and Molecular Epidemiology. Rome, Italy.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.
University Campus Bio‐Medico of Rome. Unit of Medical Statistics and Molecular Epidemiology. Rome, Italy.
University Campus Bio‐Medico of Rome. Internal Medicine Unit. Rome, Italy.
University Campus Bio‐Medico of Rome. Unit of Clinical Laboratory Sciences. Rome, Italy.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.
Abstract: There is a worldwide concern about the new coronavirus 2019-nCoV as a global public health threat. In this article, we provide a preliminary evolutionary and molecular epidemiological analysis of this new virus. A phylogenetic tree has been built using the 15 available whole genome sequences of 2019-nCoV, 12 whole genome sequences of 2019-nCoV, and 12 highly similar whole genome sequences available in gene bank (five from the severe acute respiratory syndrome, two from Middle East respiratory syndrome, and five from bat SARS-like coronavirus). Fast unconstrained Bayesian approximation analysis shows that the nucleocapsid and the spike glycoprotein have some sites under positive pressure, whereas homology modeling revealed some molecular and structural differences between the viruses. The phylogenetic tree showed that 2019-nCoV significantly clustered with bat SARS-like coronavirus sequence isolated in 2015, whereas structural analysis revealed mutation in Spike Glycoprotein and nucleocapsid protein. From these results, the new 2019-nCoV is distinct from SARS virus, probably trasmitted from bats after mutation conferring ability to infect humans.
Keywords: Coronavirus
Macromolecular design
Coronavirus
Epidemiology
COVID-19
keywords: Coronavírus
Epidemiologia
Coronavirus
Design macromolecular
Issue Date: 2020
Publisher: Wiley
Related document: https://www.arca.fiocruz.br/handle/icict/40022
Citation: BENVENUTO, Domenico et al. The 2019‐new coronavirus epidemic: Evidence for virus evolution. Journal of Medical Virology, p. 1-5, 2020.
Description: Devido a pandemia mundial do COVID-19, o artigo da revista foi liberado em acesso aberto durante o ano de 2020, visando divulgação e disseminação.
Em decorrência da pandemia decretada pela OMS em 2020, o artigo encontra-se em acesso aberto.
DOI: 10.1002/jmv.25688
ISSN: 0146-6615
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos
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