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MYCOBACTERIUM TUBERCULOSIS COMPLEX GENETIC DIVERSITY: MINING THE FOURTH INTERNATIONAL SPOLIGOTYPING DATABASE (SPOLDB4) FOR CLASSIFICATION, POPULATION GENETICS AND EPIDEMIOLOGY
Diversidade genética
Genètica populaciona
Epidemiologia
Classificação
Quarto banco de dados internacional de espoligotipagem
Genetic diversity
Fourth international spoligotyping database
Population genetics
Epidemiology
Classification
AUTHORS - Karine Brudey1, Jeffrey R Driscoll2, Leen Rigouts3, Wolfgang M Prodinger4, Andrea Gori5, Sahal A Al-Hajoj6, , Caroline Allix7, Liselotte Aristimuño8, Jyoti Arora9, Viesturs Baumanis10, Lothar Binder11, Patricia Cafrune12, Angel Cataldi13, Soonfatt Cheong14, Roland Diel15, Christopher Ellermeier16, Jason T Evans17, Maryse Fauville-Dufaux7, Séverine Ferdinand1, Dario Garcia de Viedma18, Carlo Garzelli19, Lidia Gazzola5, Harrison M Gomes20, M Cristina Guttierez21, Peter M Hawkey17, Paul D van Helden22, Gurujaj V Kadival23, Barry N Kreiswirth24, Kristin Kremer25, Milan Kubin26, Savita P Kulkarni23, Benjamin Liens1, Troels Lillebaek27, Ho Minh Ly28, Carlos Martin29, Christian Martin30, Igor Mokrousov31, Olga Narvskaïa31, Yun Fong Ngeow14, Ludmilla Naumann32, Stefan Niemann33, Ida Parwati34, Zeaur Rahim35, Voahangy Rasolofo- Razanamparany36, Tiana Rasolonavalona36, M Lucia Rossetti12, Sabine Rüsch- Gerdes33, Anna Sajduda37, Sofia Samper38, Igor G Shemyakin39, Urvashi B Singh9, Akos Somoskovi40, Robin A Skuce41, Dick van Soolingen25, Elisabeth M Streicher22, Philip N Suffys20, Enrico Tortoli42, Tatjana Tracevska10, Véronique Vincent21, Tommie C Victor22, Robin M Warren22, Sook Fan Yap14, Khadiza Zaman35, Françoise Portaels3, Nalin Rastogi*1 and Christophe Sola*1 - AFFILIATIONS - 1Unité de la Tuberculose et des Mycobactéries, Institut Pasteur de Guadeloupe, Guadeloupe, 2Wadsworth Center, New York State Dept. of Health, Albany, NY, USA, 3Mycobacteriology Unit, Prince Leopold Institute of Tropical Medicine, Antwerp, Belgium, 4Dept. Hygiene Microbiology and Social Medicine, Innsbruck Medical University, Innsbruck, Austria, 5Dept of Infectious Diseases, Institut of Infectious Diseases, Milano, Italy, 6Department of Comparative Medicine, King Faisal specialist Hospital and Research Center, Riyadh, Saudi Arabia, 7Laboratoire de la Tuberculose, Institut Pasteur de Bruxelles, Belgique, 8Universidad Centrooccidental Lisandro Alvarado, Barquisimeto, Venezuela and Universidad de Zaragoza, Spain, 9All India Institute of Medical Sciences, New Delhi, India, 10Biomedical Research and Study Center, Riga, Latvia, 11Institut for Hygiene, Microbiologie and Tropical Medicine, Austria, 12Universidade Federal do Rio Grande de Soul, Brazil, 13Instituto de Biotecnologia INTA, Castelar, Argentina, 14Dept of Medical Microbiology and Pathology, faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia, School of Public Health, 15University of Düsseldorf, Heinrich-Heine-University, Düsseldorf, 16Dept of Internal Medicine II, University of Regensbourg, Germany, 17Public Health Laboratory, Hearltlands Hospital, Birmingham, UK, 18Dept of Clinical Microbiology and Infectious Diseases, Hospital Gregorio Marañon, Madrid, Spain, 19Dept. of Experimental Pathology, Medical Biotechnology, Infection and Epidemiology, Pisa University, Pisa, Italy, 20Laboratory of Molecular Biology applied to Mycobacteria, Dept. Mycobacteriosis, Oswaldo Cruz Institute, Rio de Janeiro, Brazil, 21Centre National de Référence des Mycobactéries, Institut Pasteur, Paris, France, 22MRC Centre for Molecular and Cellular Biology, Dept of medical Biochemistry, University of Stellenbosch, Tygerberg, South Africa, 23Laboratory Nuclear Medicine Section, Isotope group, Bhabha Atomic Research Centre c/T.M.H. Annexe, Parel, Mumbai-400012, India, 24Public Health Research Institute, Newark, NJ, USA, 25Mycobacteria reference unit, Diagnostic Laboratory for Infectious Diseases and Perinatal Screening, National Institute of Public Health and the Environment, Bilthoven, The Netherlands, 26Municipal Institute of Hygiene, Prague, Czech Republic, 27Statens Serum Institute, Int. Ref. lab. for Mycobacteriology, Copenhagen Denmark, 28Institute of Hygiene and Epidemiology, Hanoi, Vietnam, 29Universidad de Zaragoza, Zaragoza, Spain, 30Laboratoire de Bactério-virologie-hygiène, CHU Dupuytren, Limoges, France, 31Institut Pasteur de Saint-Petersbourg, Saint Petersbourg, Russia, 32Bavarian Health and Food Safety Authority, Oberschleissheim, Germany, 33Forschungszentrum, National Reference Center for Mycobacteria, Borstel, Germany, 34Dept of Clinical Pathology, Padjadjaran University, Dr. Hasan Sadikin Hospital, Bandung, Indonesia, 35Tuberculosis Laboratory, International Centre for Diarrhoeal Research, Dhaka, Bangladesh, 36Institut Pasteur de Madagascar, Tananarive, Madagascar, 37Dept of Genetics of Microorganisms, University of Lódz, Lodz, Poland, 38Servicio Microbiología, Hospital Universitario Miguel Servet, Zaragoza, Spain, 39State Research Center for Applied Microbiology, Obolensk, Russian Federation, 40Dept. of Respiratory Medicine School of Medicine Semmelweis University, Budapest, Hungary, 41Veterinary Sciences Division, Department of agriculture for Northern Ireland, Belfast, UK and 42Centro regionale di Riferimento per i Micobatteri, Laboratorio de Microbiologia e Virologia, Ospedale Careggi, Firenze, Italy.
Author
Affilliation
Abstract
The Direct Repeat locus of the Mycobacterium tuberculosis complex (MTC) is a member of
the CRISPR (Clustered regularly interspaced short palindromic repeats) sequences family. Spoligotyping is
the widely used PCR-based reverse-hybridization blotting technique that assays the genetic diversity of this
locus and is useful both for clinical laboratory, molecular epidemiology, evolutionary and population
genetics. It is easy, robust, cheap, and produces highly diverse portable numerical results, as the result of
the combination of (1) Unique Events Polymorphism (UEP) (2) Insertion-Sequence-mediated genetic
recombination. Genetic convergence, although rare, was also previously demonstrated. Three previous
international spoligotype databases had partly revealed the global and local geographical structures of MTC
bacilli populations, however, there was a need for the release of a new, more representative and extended,
international spoligotyping database.
Keywords in Portuguese
Mycobacterium tuberculosisDiversidade genética
Genètica populaciona
Epidemiologia
Classificação
Quarto banco de dados internacional de espoligotipagem
Keywords
Mycobacterium tuberculosisGenetic diversity
Fourth international spoligotyping database
Population genetics
Epidemiology
Classification
Publisher
BioMed Central
Citation
BRUDEY, Karine et a. Mycobacterium tuberculosis complex genetic diversity: mining the fourth international spoligotyping database (SpolDB4) for classification, population genetics and epidemiology. BMC Microbiology, v. 6, n. 23, p. 1-17, 2006.DOI
10.1186/1471-2180-6-23ISSN
1471-2180Notes
Philip N Suffys; Harrison M Gomes. Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Laboratory of Molecular Biology applied to Mycobacteria, Dept. Mycobacteriosis. Rio de Janeiro, RJ, Brazil.AUTHORS - Karine Brudey1, Jeffrey R Driscoll2, Leen Rigouts3, Wolfgang M Prodinger4, Andrea Gori5, Sahal A Al-Hajoj6, , Caroline Allix7, Liselotte Aristimuño8, Jyoti Arora9, Viesturs Baumanis10, Lothar Binder11, Patricia Cafrune12, Angel Cataldi13, Soonfatt Cheong14, Roland Diel15, Christopher Ellermeier16, Jason T Evans17, Maryse Fauville-Dufaux7, Séverine Ferdinand1, Dario Garcia de Viedma18, Carlo Garzelli19, Lidia Gazzola5, Harrison M Gomes20, M Cristina Guttierez21, Peter M Hawkey17, Paul D van Helden22, Gurujaj V Kadival23, Barry N Kreiswirth24, Kristin Kremer25, Milan Kubin26, Savita P Kulkarni23, Benjamin Liens1, Troels Lillebaek27, Ho Minh Ly28, Carlos Martin29, Christian Martin30, Igor Mokrousov31, Olga Narvskaïa31, Yun Fong Ngeow14, Ludmilla Naumann32, Stefan Niemann33, Ida Parwati34, Zeaur Rahim35, Voahangy Rasolofo- Razanamparany36, Tiana Rasolonavalona36, M Lucia Rossetti12, Sabine Rüsch- Gerdes33, Anna Sajduda37, Sofia Samper38, Igor G Shemyakin39, Urvashi B Singh9, Akos Somoskovi40, Robin A Skuce41, Dick van Soolingen25, Elisabeth M Streicher22, Philip N Suffys20, Enrico Tortoli42, Tatjana Tracevska10, Véronique Vincent21, Tommie C Victor22, Robin M Warren22, Sook Fan Yap14, Khadiza Zaman35, Françoise Portaels3, Nalin Rastogi*1 and Christophe Sola*1 - AFFILIATIONS - 1Unité de la Tuberculose et des Mycobactéries, Institut Pasteur de Guadeloupe, Guadeloupe, 2Wadsworth Center, New York State Dept. of Health, Albany, NY, USA, 3Mycobacteriology Unit, Prince Leopold Institute of Tropical Medicine, Antwerp, Belgium, 4Dept. Hygiene Microbiology and Social Medicine, Innsbruck Medical University, Innsbruck, Austria, 5Dept of Infectious Diseases, Institut of Infectious Diseases, Milano, Italy, 6Department of Comparative Medicine, King Faisal specialist Hospital and Research Center, Riyadh, Saudi Arabia, 7Laboratoire de la Tuberculose, Institut Pasteur de Bruxelles, Belgique, 8Universidad Centrooccidental Lisandro Alvarado, Barquisimeto, Venezuela and Universidad de Zaragoza, Spain, 9All India Institute of Medical Sciences, New Delhi, India, 10Biomedical Research and Study Center, Riga, Latvia, 11Institut for Hygiene, Microbiologie and Tropical Medicine, Austria, 12Universidade Federal do Rio Grande de Soul, Brazil, 13Instituto de Biotecnologia INTA, Castelar, Argentina, 14Dept of Medical Microbiology and Pathology, faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia, School of Public Health, 15University of Düsseldorf, Heinrich-Heine-University, Düsseldorf, 16Dept of Internal Medicine II, University of Regensbourg, Germany, 17Public Health Laboratory, Hearltlands Hospital, Birmingham, UK, 18Dept of Clinical Microbiology and Infectious Diseases, Hospital Gregorio Marañon, Madrid, Spain, 19Dept. of Experimental Pathology, Medical Biotechnology, Infection and Epidemiology, Pisa University, Pisa, Italy, 20Laboratory of Molecular Biology applied to Mycobacteria, Dept. Mycobacteriosis, Oswaldo Cruz Institute, Rio de Janeiro, Brazil, 21Centre National de Référence des Mycobactéries, Institut Pasteur, Paris, France, 22MRC Centre for Molecular and Cellular Biology, Dept of medical Biochemistry, University of Stellenbosch, Tygerberg, South Africa, 23Laboratory Nuclear Medicine Section, Isotope group, Bhabha Atomic Research Centre c/T.M.H. Annexe, Parel, Mumbai-400012, India, 24Public Health Research Institute, Newark, NJ, USA, 25Mycobacteria reference unit, Diagnostic Laboratory for Infectious Diseases and Perinatal Screening, National Institute of Public Health and the Environment, Bilthoven, The Netherlands, 26Municipal Institute of Hygiene, Prague, Czech Republic, 27Statens Serum Institute, Int. Ref. lab. for Mycobacteriology, Copenhagen Denmark, 28Institute of Hygiene and Epidemiology, Hanoi, Vietnam, 29Universidad de Zaragoza, Zaragoza, Spain, 30Laboratoire de Bactério-virologie-hygiène, CHU Dupuytren, Limoges, France, 31Institut Pasteur de Saint-Petersbourg, Saint Petersbourg, Russia, 32Bavarian Health and Food Safety Authority, Oberschleissheim, Germany, 33Forschungszentrum, National Reference Center for Mycobacteria, Borstel, Germany, 34Dept of Clinical Pathology, Padjadjaran University, Dr. Hasan Sadikin Hospital, Bandung, Indonesia, 35Tuberculosis Laboratory, International Centre for Diarrhoeal Research, Dhaka, Bangladesh, 36Institut Pasteur de Madagascar, Tananarive, Madagascar, 37Dept of Genetics of Microorganisms, University of Lódz, Lodz, Poland, 38Servicio Microbiología, Hospital Universitario Miguel Servet, Zaragoza, Spain, 39State Research Center for Applied Microbiology, Obolensk, Russian Federation, 40Dept. of Respiratory Medicine School of Medicine Semmelweis University, Budapest, Hungary, 41Veterinary Sciences Division, Department of agriculture for Northern Ireland, Belfast, UK and 42Centro regionale di Riferimento per i Micobatteri, Laboratorio de Microbiologia e Virologia, Ospedale Careggi, Firenze, Italy.
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