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2025-01-01
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FLAVONOIDS AND TRYPANOCIDAL ACTIVITY OF BULGARIAN PROPOLIS
Prytzyk, Eliane et al. | Date Issued: 2003
Author
Prytzyk, Eliane
Dantas, Andreia P.
Salomão, Kelly
Pereira, Alberto S.
Bankova, Vassya S.
Castro, Solange L. de
Aquino Neto, Francisco R.
Affilliation
Universidade Federal do Rio de Janeiro. Instituto de Química. Ladetec. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Ultraestrutura e Biologia Celular. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Ultraestrutura e Biologia Celular. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Instituto de Química. Ladetec. Rio de Janeiro, RJ, Brasil.
Bulgarian Academy of Science. Institute of Organic Chemistry with Centre of Phytochemistry. Sofia, Bulgaria.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Ultraestrutura e Biologia Celular. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Instituto de Química. Ladetec. Rio de Janeiro, RJ, Brasil.
Abstract
Acetone and ethanol extracts of two Bulgarian propolis samples (Bur and Lov) were investigated by high temperature high resolution gas chromatography coupled to mass spectrometry (HT-HRGC-MS), and their activity against Trypanosoma cruzi was evaluated. The ethanol extracts—Et-Bur and Et-Lov—showed similar composition, with a high content of flavonoids, and strong inhibitory activity against T. cruzi proliferative epimastigotes, which were more susceptible than trypomastigotes. In the presence of blood, the activity of Et-Bur or Et-Lov against trypomastigotes was similar to that of the standard drug, crystal violet. Both extracts also showed similar and significant activity against Staphylococcus aureus and Candida albicans, while being inactive against Escherichia coli. The acetone extract, Ket-Bur, was more active than Et-Bur against both forms of T. cruzi.
Keywords in Portuguese
Própolis
Trypanosoma cruzi
Flavonoides
Atividade antifúngica
Atividade antibacteriana
Cromatografia gasosa de alta temperatura
 
Keywords
Propolis
Flavonoids
High temperature gas chromatography
Trypanosoma cruzi
Antibacterial activity
Antifungal activity
 
Publisher
Elsevier
Citation
PRYTZYK, Eliane et al. Flavonoids and trypanocidal activity of Bulgarian propolis. Journal of Ethnopharmacology, v. 88, p. 189-193, 2003.
DOI
10.1016/S0378-8741(03)00210-1
ISSN
0378-8741