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2022-01-01
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EVALUATION OF PHTHALAZINONE PHOSPHODIESTERASE INHIBITORS WITH IMPROVED ACTIVITY AND SELECTIVITY AGAINST TRYPANOSOMA CRUZI
Araújo, Julianna Siciliano de et al. | Date Issued: 2020
Author
Araújo, Julianna Siciliano de
Silva, Patrícia Bernardino da
Batista, Marcos Meuser
Peres, Raiza Brandão
Santos, Camila Cardoso
Kalejaiye, Titilola D.
Munday, Jane C.
De Heuvel, Erik
Sterk, Geert Jan
Augustyns, Koen
Salado, Irene G.
Matheeussen, An
De Esch, Iwan
De Koning, Harry P.
Leurs, Rob
Maes, Louis
Soeiro, Maria de Nazaré Correia
Affilliation
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
University of Glasgow. College of Medical, Veterinary & Life Sciences, Institute of Infection, Immunity & Inflammation. Glasgow, UK.
University of Glasgow. College of Medical, Veterinary & Life Sciences, Institute of Infection, Immunity & Inflammation. Glasgow, UK.
Vrije Universiteit Amsterdam. Amsterdam Institute for Molecules, Medicines & Systems. Medicinal Chemistry. Amsterdam, The Netherlands.
Vrije Universiteit Amsterdam. Amsterdam Institute for Molecules, Medicines & Systems. Medicinal Chemistry. Amsterdam, The Netherlands.
University of Antwerp. Laboratory of Medicinal Chemistry. Antwerp, Belgium.
University of Antwerp. Laboratory of Medicinal Chemistry. Antwerp, Belgium.
University of Antwerp. Laboratory for Microbiology, Parasitology and Hygiene. Antwerp, Belgium.
Vrije Universiteit Amsterdam. Amsterdam Institute for Molecules, Medicines & Systems. Medicinal Chemistry. Amsterdam, The Netherlands.
University of Glasgow. College of Medical, Veterinary & Life Sciences, Institute of Infection, Immunity & Inflammation. Glasgow, UK.
Vrije Universiteit Amsterdam. Amsterdam Institute for Molecules, Medicines & Systems. Medicinal Chemistry. Amsterdam, The Netherlands.
University of Antwerp. Laboratory for Microbiology, Parasitology and Hygiene. Antwerp, Belgium.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
Abstract
Chagas' disease, caused by the protozoan parasite Trypanosoma cruzi, needs urgent alternative therapeutic options as the treatments currently available display severe limitations, mainly related to efficacy and toxicity.
Keywords in Portuguese
Inibidores da ftalazinona fosfodiesterase
Trypanosoma cruzi
Avaliação
 
Keywords
Evaluation
Phthalazinone phosphodiesterase inhibitor
Trypanosoma cruzi
 
Publisher
Oxford University Press
Citation
ARAÚJO, Julianna Siciliano de et al. Evaluation of phthalazinone phosphodiesterase inhibitors with improved activity and selectivity against Trypanosoma cruzi, J. Antimicrob. Chemother., v. 75, p. 958-967, Dec. 2019.
DOI
10.1093/jac/dkz516
ISSN
0305-7453