Culex quinquefasciatus is a successful invasive species broadly distributed in subtropical regions, including Brazil. It is an extremely annoying mosquito due to its nocturnal biting behavior, in high-density populations and it is a potential bridge between sylvatic arbovirus from birds to man in urban territories. Herein, we present a review concerning the methods of chemical control employed against Cx. quinquefasciatus in Brazil since the 1950’s and insecticide resistance data registered in the literature. As there is no specifc national programme for Cx. quinquefasciatus control in Brazil, the selection of insecticide resistance is likely due in part to the well-designed chemical campaigns against Aedes aegypti and the elevated employment of insecticides by households and private companies. There are very few publications about insecticide resistance in Cx. quinquefasciatus from Brazil when compared to Ae. aegypti. Nevertheless, resistance to organophosphates, carbamate, DDT, pyrethroids and biolarvicides has been registered in Cx. quinquefasciatus populations from distinct localities of the country. Concerning physiological mechanisms selected for resistance, distinct patterns of esterases, as well as mutations in the acetylcholinesterase (ace-1) and voltagegated sodium channel (NaV) genes, have been identifed in natural populations. Given environmental changes and socioeconomical issues in the cities, in recent years we have been experiencing an increase in the number of disease cases caused by arboviruses, which may involve Cx. quinquefasciatus participation as a key vector. It is urgent to better understand the efciency and susceptibility status to insecticides, as well as the genetic background of known resistant mechanisms already present in Cx. quinquefasciatus populations for an efective and rapid chemical control when eventually required.