Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/4072
Title: Collagen arrangement in hepatic granuloma in mice infected with Schistosoma mansoni: dependence on fiber radiation centers
Authors: Lenzi, Henrique Leonel
Kimmel, E.
Schechtman, H.
Machado, Marcelo Pelajo
Vale, Bruno Silva
Panasco, Monica de Souza
Lenzi, Jane A.
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.
Israel Institute of Technology. Department of Agricultural Engineering, Technion. Haifa, Israel
Fundação Oswaldo Cruz. Presidência. Programa de Computação Científica. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.
Abstract: The collagen structure of isolated and in situ liver granuloma from Swiss Webster mice infected with Schistosoma mansoni was sequentially and three-dimensionally analyzed during different times of infection (early acute, acute, transitional acute-chronic, and chronic phases) by laser scanning confocal microscopy and electron scanning variable vacuum microscopy. The initial granuloma structure is characterized by vascular collagen residues and by anchorage points (or fiber radiation centers), from where collagenous fibers are angularly shed and self-assembled. During the exudative-productive stage, the self-assembly of these fibers minimizes energy and mass through continuous tension and focal compression. The curvature or angles between collagen fibers probably depends on the fibroblastic or myofibroblastic organization of stress fibers. Gradually, the loose unstable lattice of the exudative-productive stage transforms into a highly packed and stable architecture as a result of progressive compactness. The three-dimensional architecture of granulomas provides increased tissue integrity, efficient distribution of soluble compounds and a haptotactic background to the cells.
Keywords: Granuloma
Schistosoma mansoni
Collagen
Extracellular matrix
Confocal microscopy
DeCS: Granuloma
Microscopia Confocal
Schistosoma mansoni
Colágeno
Matriz Extracelular
Issue Date: 1999
Publisher: Associação Brasileira de Divulgação Científica
Citation: Lenzi, H.L. et al. Collagen arrangement in hepatic granuloma in mice infected with Schistosoma mansoni: dependence on fiber radiation centers. Brazilian Journal of Medical and Biological Research, Ribeirão Preto, v.32, n.5, p.639-643, May 1999.
DOI: http://dx.doi.org/10.1590/S0100-879X1999000500018
ISSN: 1414-431X
Copyright: open access
Appears in Collections:Presidência Fiocruz – Artigos de Periódicos
IOC - Artigos de Periódicos

Files in This Item:
File Description SizeFormat 
Collagen arrangement in hepatic.pdf451.83 kBAdobe PDFThumbnail
View/Open


FacebookTwitterDeliciousLinkedInGoogle BookmarksBibTex Format mendeley Endnote DiggMySpace

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.