| Author | Teles, Yanna C. F. | |
| Author | Ribeiro Filho, Jaime | |
| Author | Bozza, Patrícia T. | |
| Author | Agra, Maria de Fátima | |
| Author | Siheri, Weam | |
| Author | Igoli, John O. | |
| Author | Gray, Alexander I. | |
| Author | Souza, Maria de Fátima V. de | |
| Access date | 2020-04-23T13:02:10Z | |
| Available date | 2020-04-23T13:02:10Z | |
| Document date | 2015 | |
| Citation | TELES, Yanna C. F. et al. Phenolic constituents from Wissadula periplocifolia (L.) C. Presl. and anti-inflammatory activity of 7,4′-di-Omethylisoscutellarein. Natural Product Research, v. 30, n. 16, p. 1880-1884, 11 Sept. 2015. | pt_BR |
| ISSN | 1478-6419 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/40928 | |
| Description | Acesso aberto em 23/04/2020 - https://doi.org/10.1080/14786419.2015.1081196 | pt_BR |
| Language | eng | pt_BR |
| Publisher | Taylor and Francis | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Malvaceae | pt_BR |
| Subject in Portuguese | Wissadula periplocifolia | pt_BR |
| Subject in Portuguese | Atividade anti-inflamatória | pt_BR |
| Title | Phenolic constituents from Wissadula periplocifolia (L.) C. Presl. and anti-inflammatory activity of 7,4'-di-O-methylisoscutellarein | en |
| Type | Article | |
| DOI | 10.1080/14786419.2015.1081196 | pt_BR |
| Abstract | This study reports the first phenolics from Wissadula genus (Malvaceae) and the anti-inflammatory activity of 7,4'-di-O-methylisoscutellarein. Using chromatographic methods, five phenolic compounds were isolated from aerial parts of Wissadula periplocifolia (L.) C. Presl. The compounds were identified as 4-hydroxybenzoic acid, 3-hydroxybenzoic acid, trans-cinnamic acid, tamgermanetin and 7,4'-di-O-methylisoscutellarein using spectroscopic methods. The flavone 7,4'-di-O-methylisoscutellarein showed anti-inflammatory activity by inhibiting neutrophils recruitment in a mice model of pleurisy and by decreasing significantly the production of cytokines IL-1β and TNF-α. | en |
| Affilliation | Universidade Federal da Paraíba. Centro de Ciências da Saúde. Pós-Graduação em Desenvolvimento e Inovação Tecnológica em Medicamentos. João Pessoa, PB, Brasil. | pt_BR |
| Affilliation | Faculdade Leão Sampaio. Juazeiro do Norte, CE, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal da Paraíba. Centro de Biotecnologia. João Pessoa, PB, Brasil. | pt_BR |
| Affilliation | University of Strathclyde. Strathclyde Institute of Pharmacy and Biomedical Sciences. Glasgow, UK. | pt_BR |
| Affilliation | University of Strathclyde. Strathclyde Institute of Pharmacy and Biomedical Sciences. Glasgow, UK. | pt_BR |
| Affilliation | University of Strathclyde. Strathclyde Institute of Pharmacy and Biomedical Sciences. Glasgow, UK. | pt_BR |
| Affilliation | Universidade Federal da Paraíba. Centro de Ciências da Saúde. Pós-Graduação em Desenvolvimento e Inovação Tecnológica em Medicamentos. João Pessoa, PB, Brasil. | pt_BR |
| Subject | Malvaceae | en |
| Subject | Wissadula periplocifolia | en |
| Subject | 7,4′-di-Omethylisoscutellarein | en |
| Subject | Antiinflammatory activity | en |
| e-ISSN | 1478-6427 | pt_BR |
