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PHENOLIC CONSTITUENTS FROM WISSADULA PERIPLOCIFOLIA (L.) C. PRESL. AND ANTI-INFLAMMATORY ACTIVITY OF 7,4'-DI-O-METHYLISOSCUTELLAREIN
Teles, Yanna C. F. et al. | Date Issued: 2015
Author
Teles, Yanna C. F.
Ribeiro Filho, Jaime
Bozza, Patrícia T.
Agra, Maria de Fátima
Siheri, Weam
Igoli, John O.
Gray, Alexander I.
Souza, Maria de Fátima V. de
Affilliation
Universidade Federal da Paraíba. Centro de Ciências da Saúde. Pós-Graduação em Desenvolvimento e Inovação Tecnológica em Medicamentos. João Pessoa, PB, Brasil.
Faculdade Leão Sampaio. Juazeiro do Norte, CE, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.
Universidade Federal da Paraíba. Centro de Biotecnologia. João Pessoa, PB, Brasil.
University of Strathclyde. Strathclyde Institute of Pharmacy and Biomedical Sciences. Glasgow, UK.
University of Strathclyde. Strathclyde Institute of Pharmacy and Biomedical Sciences. Glasgow, UK.
University of Strathclyde. Strathclyde Institute of Pharmacy and Biomedical Sciences. Glasgow, UK.
Universidade Federal da Paraíba. Centro de Ciências da Saúde. Pós-Graduação em Desenvolvimento e Inovação Tecnológica em Medicamentos. João Pessoa, PB, Brasil.
Abstract
This study reports the first phenolics from Wissadula genus (Malvaceae) and the anti-inflammatory activity of 7,4'-di-O-methylisoscutellarein. Using chromatographic methods, five phenolic compounds were isolated from aerial parts of Wissadula periplocifolia (L.) C. Presl. The compounds were identified as 4-hydroxybenzoic acid, 3-hydroxybenzoic acid, trans-cinnamic acid, tamgermanetin and 7,4'-di-O-methylisoscutellarein using spectroscopic methods. The flavone 7,4'-di-O-methylisoscutellarein showed anti-inflammatory activity by inhibiting neutrophils recruitment in a mice model of pleurisy and by decreasing significantly the production of cytokines IL-1β and TNF-α.
Keywords in Portuguese
Malvaceae
Wissadula periplocifolia
Atividade anti-inflamatória
 
Keywords
Malvaceae
Wissadula periplocifolia
7,4′-di-Omethylisoscutellarein
Antiinflammatory activity
 
Publisher
Taylor and Francis
Citation
TELES, Yanna C. F. et al. Phenolic constituents from Wissadula periplocifolia (L.) C. Presl. and anti-inflammatory activity of 7,4′-di-Omethylisoscutellarein. Natural Product Research, v. 30, n. 16, p. 1880-1884, 11 Sept. 2015.
DOI
10.1080/14786419.2015.1081196
ISSN
1478-6419
Notes
Acesso aberto em 23/04/2020 - https://doi.org/10.1080/14786419.2015.1081196