| Author | Boité, Mariana C. | |
| Author | Späth, Gerald F. | |
| Author | Bussotti, Giovanni | |
| Author | Porrozzi, Renato | |
| Author | Morgado, Fernanda N. | |
| Author | Llewellyn, Martin | |
| Author | Schwabl, Philipp | |
| Author | Cupolillo, Elisa | |
| Access date | 2020-04-28T18:51:16Z | |
| Available date | 2020-04-28T18:51:16Z | |
| Document date | 2019 | |
| Citation | BOITÉ, Mariana C. et al. Trans-Atlantic Spillover: Deconstructing the Ecological Adaptation of Leishmania infantum in the Americas. Genes, v. 11, n. 4, 11p, 2020. | pt_BR |
| ISSN | 2073-4425 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/41021 | |
| Language | eng | pt_BR |
| Publisher | MDPI | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Leishmania | pt_BR |
| Subject in Portuguese | Leishmaniose visceral | pt_BR |
| Subject in Portuguese | Américas | pt_BR |
| Subject in Portuguese | Instabilidade do genoma | pt_BR |
| Subject in Portuguese | Adaptação | pt_BR |
| Title | Trans-Atlantic Spill Over: Deconstructing the Ecological Adaptation of Leishmania infantum in the Americas | pt_BR |
| Type | Article | |
| DOI | 10.3390/genes11010004 | |
| Abstract | Pathogen fitness landscapes change when transmission cycles establish in non-native environments or spill over into new vectors and hosts. The introduction of Leishmania infantum in the Americas into the Neotropics during European colonization represents a unique case study to investigate the mechanisms of ecological adaptation of this important parasite. Defining the evolutionary trajectories that drive L. infantum fitness in this new environment are of great public health importance as they will allow unique insight into pathways of host/pathogen co-evolution and their consequences for region-specific changes in disease manifestation. This review summarizes current knowledge on L. infantum genetic and phenotypic diversity in the Americas and its possible role in the unique epidemiology of visceral leishmaniasis (VL) in the New World. We highlight the importance of appreciating adaptive molecular mechanisms in L. infantum to understand the parasites' successful establishment on the continent. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmaniose. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Institut Pasteur, INSERN U1201. Department of Parasites and Insect Vectors.Laboratory of Molecular Parasitology and Signaling. Paris, France. | pt_BR |
| Affilliation | Institut Pasteur, INSERN U1201. Department of Parasites and Insect Vectors.Laboratory of Molecular Parasitology and Signaling. Paris, France / Institut Pasteur-Bioinformatics and Biostatistics Hub-C3BI, USR 3756 IP CNRS, 75015 Paris, France. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmaniose. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmaniose. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | University of Glasgow. Institute of Biodiversity, Animal Health & Comparative Medicine. Glasgow, UK. | pt_BR |
| Affilliation | University of Glasgow. Institute of Biodiversity, Animal Health & Comparative Medicine. Glasgow, UK. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmaniose. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Leishmania | pt_BR |
| Subject | Visceral leishmaniasis; | pt_BR |
| Subject | Americas | pt_BR |
| Subject | Genome instability | pt_BR |
| Subject | Adaptation | pt_BR |
