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TRANS-ATLANTIC SPILL OVER: DECONSTRUCTING THE ECOLOGICAL ADAPTATION OF LEISHMANIA INFANTUM IN THE AMERICAS
Boité, Mariana C. et al. | Date Issued: 2019
Author
Boité, Mariana C.
Späth, Gerald F.
Bussotti, Giovanni
Porrozzi, Renato
Morgado, Fernanda N.
Llewellyn, Martin
Schwabl, Philipp
Cupolillo, Elisa
Affilliation
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmaniose. Rio de Janeiro, RJ, Brasil.
Institut Pasteur, INSERN U1201. Department of Parasites and Insect Vectors.Laboratory of Molecular Parasitology and Signaling. Paris, France.
Institut Pasteur, INSERN U1201. Department of Parasites and Insect Vectors.Laboratory of Molecular Parasitology and Signaling. Paris, France / Institut Pasteur-Bioinformatics and Biostatistics Hub-C3BI, USR 3756 IP CNRS, 75015 Paris, France.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmaniose. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmaniose. Rio de Janeiro, RJ, Brasil.
University of Glasgow. Institute of Biodiversity, Animal Health & Comparative Medicine. Glasgow, UK.
University of Glasgow. Institute of Biodiversity, Animal Health & Comparative Medicine. Glasgow, UK.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmaniose. Rio de Janeiro, RJ, Brasil.
Abstract
Pathogen fitness landscapes change when transmission cycles establish in non-native environments or spill over into new vectors and hosts. The introduction of Leishmania infantum in the Americas into the Neotropics during European colonization represents a unique case study to investigate the mechanisms of ecological adaptation of this important parasite. Defining the evolutionary trajectories that drive L. infantum fitness in this new environment are of great public health importance as they will allow unique insight into pathways of host/pathogen co-evolution and their consequences for region-specific changes in disease manifestation. This review summarizes current knowledge on L. infantum genetic and phenotypic diversity in the Americas and its possible role in the unique epidemiology of visceral leishmaniasis (VL) in the New World. We highlight the importance of appreciating adaptive molecular mechanisms in L. infantum to understand the parasites' successful establishment on the continent.
Keywords in Portuguese
Leishmania
Leishmaniose visceral
Américas
Instabilidade do genoma
Adaptação
 
Keywords
Leishmania
Visceral leishmaniasis;
Americas
Genome instability
Adaptation
 
Publisher
MDPI
Citation
BOITÉ, Mariana C. et al. Trans-Atlantic Spillover: Deconstructing the Ecological Adaptation of Leishmania infantum in the Americas. Genes, v. 11, n. 4, 11p, 2020.
DOI
10.3390/genes11010004
ISSN
2073-4425