| Author | Sartori, Priscila Verchai Uaska | |
| Author | Penna, Gerson Oliveira | |
| Author | Bührer-Sékula, Samira | |
| Author | Pontes, Maria Araci de Andrade | |
| Author | Gonçalves, Heitor de Sá | |
| Author | Cruz, Rossilene | |
| Author | Virmond, Marcos da Cunha Lopes | |
| Author | Baptista, Ida Maria Foschiani Dias | |
| Author | Rosa, Patricia Sammarco | |
| Author | Penna, Maria Lucia Fernandes | |
| Author | Medeiros Fava, Vinicius | |
| Author | Stefani, Mariane Martins de Araújo | |
| Author | Távora Mira, Marcelo | |
| Access date | 2020-05-06T19:10:17Z | |
| Available date | 2020-05-06T19:10:17Z | |
| Document date | 2020 | |
| Citation | SARTORI, Priscila Verchai Uaska et al. Human genetic susceptibility of Leprosy recurrence. Scientific Reports, [Nova york], v. 10, n. 1284, p. 1-5, jun. 2020. | pt_BR |
| ISSN | 2045-2322 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/41139 | |
| Sponsorship | UMDT Clinical Trial e Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | pt_BR |
| Language | eng | pt_BR |
| Publisher | Springer Nature | pt_BR |
| Rights | open access | pt_BR |
| MeSH | Leprosy | pt_BR |
| MeSH | Mycobacterium leprae | pt_BR |
| MeSH | Genes, Bacterial | pt_BR |
| MeSH | Human Genetics | pt_BR |
| MeSH | Communicable Diseases | pt_BR |
| Title | Human genetic susceptibility of Leprosy recurrence | pt_BR |
| Type | Article | pt_BR |
| Abstract | Host genetic susceptibility to leprosy has been intensively investigated over the last decades; however, there are no studies on the role of genetic variants in disease recurrence. A previous initiative identified three recurrent cases of leprosy for which none of the M. leprae strains, as obtained in the first and the second diagnosis, had any known genomic variants associated to resistance to Multidrug therapy; in addition, whole genome sequencing indicated that the same M. leprae was causing two out of the three recurrences. Thus, these individuals were suspected of being particularly susceptible to M. leprae infection, either as relapse or reinfection. To verify this hypothesis, 19 genetic markers distributed across 11 loci (14 genes) classically associated with leprosy were genotyped in the recurrent and in three matching non-recurrent leprosy cases. An enrichment of risk alleles was observed in the recurrent cases, suggesting the existence of a particularly high susceptibility genetic profile among leprosy patients predisposing to disease recurrence. | pt_BR |
| Affilliation | Pontifícia Universidade Católica do Paraná. Faculdade de Medicina. Programa de Pós-graduação em Ciências da Saúde. Curitiba, PR, Brasil. | pt_BR |
| Affilliation | Universidade de Brasília. Faculdade de Medicina. Núcleo de Medicina Tropical. Brasília, DF, Brasil / Fundação Oswaldo Cruz. Fiocruz Brasília. Brasília, DF, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Goiás. Instituto de Patologia Tropical e Saúde Pública. Goiânia, GO, Brasil. | pt_BR |
| Affilliation | Dona Libânia Dermatology Centre. Fortaleza, CE, Brasil. | pt_BR |
| Affilliation | Fundação de Dermatologia Tropical e Venereologia Alfredo da Matta. Manaus, AM, Brasil. | pt_BR |
| Affilliation | Instituto Lauro de Souza Lima. Bauru, SP, Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Departamento de Epidemiologia e Bioestatística. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | McGill University Health Centre. Infectious Diseases and Immunity in Global Health Program. Montreal, QC, Canada. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Fiocruz Brasília. Brasília, DF, Brasil. | pt_BR |
| Affilliation | Pontifícia Universidade Católica do Paraná. Faculdade de Medicina. Programa de Pós-graduação em Ciências da Saúde. Curitiba, PR, Brasil. | pt_BR |
| Subject | Leprosy | pt_BR |
| Subject | Human genetic | pt_BR |
| Subject | Mycobacterium leprae | pt_BR |
| DeCS | Hanseníase | pt_BR |
| DeCS | Mycobacterium leprae | pt_BR |
| DeCS | Genes Bacterianos | pt_BR |
| DeCS | Genética Humana | pt_BR |
| DeCS | Doenças Transmissíveis | pt_BR |
| e-ISSN | 10.1038/s41598-020-58079-3 | |
