| Author | Lockwood, Diana N. | |
| Author | Krishnamurthy, Padebettu | |
| Author | Kumar, Bhushan | |
| Author | Penna, Gerson Oliveira | |
| Access date | 2020-05-07T16:19:34Z | |
| Available date | 2020-05-07T16:19:34Z | |
| Document date | 2018 | |
| Citation | LOCKWOOD, Diana N. J. et al. Single-dose rifampicin chemoprophylaxis protects those who need it least and is not a cost-effective intervention. PLOS Neglected Tropical Diseases, [San Francisco], v. 12, n. 6, p. 1-4, jun. 2018. | pt_BR |
| ISSN | 1935-2727 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/41150 | |
| Description | Gerson Oliveira Penna - Fundação Oswaldo Cruz. Fiocruz Brasília. Brasília, DF, Brasil. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento. | pt_BR |
| Language | eng | pt_BR |
| Publisher | Public Library of Science | pt_BR |
| Rights | open access | pt_BR |
| MeSH | Chemoprevention | pt_BR |
| MeSH | Cost-Benefit Analysis | pt_BR |
| MeSH | Family Characteristics | pt_BR |
| MeSH | Leprosy, Multibacillary | pt_BR |
| MeSH | Preventive Health Services | pt_BR |
| MeSH | Rifampin | pt_BR |
| MeSH | Mycobacterium leprae | pt_BR |
| Title | Single-dose rifampicin chemoprophylaxis protects those who need it least and is not a cost-effective intervention | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1371/journal.pntd.0006403 | |
| Abstract | Single-dose rifampicin (SDR) treatment being offered to household contacts of new leprosy patients is being practiced by the Indian National Leprosy Programme since November 2017. We are concerned, because this is not an effective method for preventing multibacillary (MB) leprosy. It does not protect against the development of MB leprosy and does not protect immediate household contacts for a reasonable period of time. There are serious ethical problems related to identifying the contacts of patients with leprosy, it is not cost effective for household contacts, and there is a possibility of the widespread use of SDR promoting the development of rifampicin resistance genes in Mycobacterium leprae. | pt_BR |
| Affilliation | London School of Hygiene and Tropical Medicine. London, United Kingdom. | pt_BR |
| Affilliation | Damien Foundation of India Trust. Chennai, India. | pt_BR |
| Affilliation | Postgraduate Institute of Medical Education and Research. Department of Dermatology, STD and Leprosy. Chandigarh, India. | pt_BR |
| Affilliation | Universidade de Brasília. Faculdade de Medicina. Núcleo de Medicina Tropical. Brasília, DF, Brasil / Fundação Oswaldo Cruz. Brasília, DF, Brasil. | pt_BR |
| Subject | Leprosy | pt_BR |
| Subject | Rifampin | pt_BR |
| Subject | Cost-benefit analysis | pt_BR |
| Subject | Preventive health services | pt_BR |
| Subject | Mycobacterium leprae | pt_BR |
| DeCS | Hanseníase | pt_BR |
| DeCS | Rifampina | pt_BR |
| DeCS | Análise custo-benefício | pt_BR |
| DeCS | Serviços Preventivos de Saúde | pt_BR |
| DeCS | Mycobacterium leprae | pt_BR |
| DeCS | Doenças Negligenciadas | pt_BR |
| DeCS | Doenças Transmissíveis | pt_BR |
