| Author | Araújo, Thália Velho Barreto de | |
| Author | Rodrigues, Laura Cunha | |
| Author | Ximenes, Ricardo Arraes de Alencar | |
| Author | Miranda-Filho, Demócrito de Barros | |
| Author | Montarroyos, Ulisses Ramos | |
| Author | Melo, Ana Paula Lopes de | |
| Author | Valongueiro, Sandra | |
| Author | Albuquerque, Maria de Fátima Pessoa Militão de | |
| Author | Souza, Wayner Vieira | |
| Author | Braga, Cynthia | |
| Author | Brandão Filho, Sinval Pinto | |
| Author | Cordeiro, Marli Tenório | |
| Author | Vazquez, Enrique | |
| Author | Cruz, Danielle di Cavalcanti Souza | |
| Author | Henriques, Cláudio Maierovitch Pessanha | |
| Author | Bezerra, Luciana Caroline Albuquerque | |
| Author | Castanha, Priscila Mayrelle da Silva | |
| Author | Dhalia, Rafael | |
| Author | Marques-Júnior, Ernesto Torres Azevedo | |
| Author | Martelli, Celina Maria Turchi | |
| Author | Microcephaly Epidemic Research Group | |
| Author | Organização Pan-Americana da Saúde | |
| Author | Instituto de Medicina Integral Professor Fernando Figueira | |
| Author | Secretaria Estadual de Saúde de Pernambuco | |
| Access date | 2020-05-18T18:53:29Z | |
| Available date | 2020-05-18T18:53:29Z | |
| Document date | 2016 | |
| Citation | ARAÚJO, Thália Velho Barreto de et al. Association between Zika virus infection and microcephaly in Brazil, January to May, 2016: preliminary report of a case-control study. Lancet, [New York], v. 16, n. 12, p. 1356-1363, Dec. 2016. | pt_BR |
| ISSN | 1474-4457 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/41272 | |
| Sponsorship | Ministério da Saúde e Organização Pan-Americana da Saúde. | pt_BR |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | open access | pt_BR |
| MeSH | Microcephaly | pt_BR |
| MeSH | Pregnancy | pt_BR |
| MeSH | Pregnancy Complications, Infectious / epidemiology | pt_BR |
| MeSH | Zika Virus Infection | pt_BR |
| Title | Association between Zika virus infection and microcephaly in Brazil, january to may, 2016: preliminary report of a case-control study | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1016/S1473-3099(16)30318-8 | |
| Abstract | Background: The microcephaly epidemic, which started in Brazil in 2015, was declared a Public Health Emergency of International Concern by WHO in 2016. We report the preliminary results of a case-control study investigating the association between microcephaly and Zika virus infection during pregnancy.
Methods: We did this case-control study in eight public hospitals in Recife, Brazil. Cases were neonates with microcephaly. Two controls (neonates without microcephaly), matched by expected date of delivery and area of residence, were selected for each case. Serum samples of cases and controls and cerebrospinal fluid samples of cases were tested for Zika virus-specific IgM and by quantitative RT-PCR. Laboratory-confirmed Zika virus infection during pregnancy was defined as detection of Zika virus-specific IgM or a positive RT-PCR result in neonates. Maternal serum samples were tested by plaque reduction neutralisation assay for Zika virus and dengue virus. We estimated crude odds ratios (ORs) and 95% CIs using a median unbiased estimator for binary data in an unconditional logistic regression model. We estimated ORs separately for cases with and without radiological evidence of brain abnormalities.Findings: Between Jan 15, 2016, and May 2, 2016, we prospectively recruited 32 cases and 62 controls. 24 (80%) of 30 mothers of cases had Zika virus infection compared with 39 (64%) of 61 mothers of controls (p=0·12). 13 (41%) of 32 cases and none of 62 controls had laboratory-confirmed Zika virus infection; crude overall OR 55·5 (95% CI 8·6–∞); OR 113·3 (95% CI 14·5–∞) for seven cases with brain abnormalities; and OR 24·7 (95% CI 2·9–∞) for four cases without brain abnormalities. Interpretation: Our data suggest that the microcephaly epidemic is a result of congenital Zika virus infection. We await further data from this ongoing study to assess other potential risk factors and to confirm the strength of association in a larger sample size. | pt_BR |
| Affilliation | Universidade Federal de Pernambuco. Departamento de Medicina Social. Recife, PE, Brasil. | pt_BR |
| Affilliation | London School of Hygiene & Tropical Medicine. Disease Epidemiology. Department of Infectious. London, UK. | pt_BR |
| Affilliation | Universidade Federal de Pernambuco. Departamento de Medicina Tropical. Recife, PE, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Pernambuco. Recife, PE, Brasil / Universidade Federal de Pernambuco. Departamento de Saúde Coletiva. Vitória de Santo Antão, PE, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Pernambuco. Departamento de Medicina Tropical. Recife, PE, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil. | pt_BR |
| Affilliation | Organização Pan-Americana da Saúde. Brasília, DF, Brasil. | pt_BR |
| Affilliation | Instituto Materno Infantil Fernando Figueira. Recife, PE, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Fiocruz Brasília. Brasília, DF, Brasil. | pt_BR |
| Affilliation | Governo Estadual de Pernambuco. Secretaria Estadual de Saúde de Pernambuco. Recife, PE, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil. | pt_BR |
| Affilliation | The Global Heath Network. Microcephaly Epidemic Research Group. Oxford, England. | pt_BR |
| Affilliation | Organização Pan-Americana da Saúde. Brasília, DF, Brasil. | pt_BR |
| Affilliation | Instituto de Medicina Integral Professor Fernando Figueira. Caruaru, PE, Brasil. | pt_BR |
| Affilliation | Governo Estadual de Pernambuco. Secretaria Estadual de Saúde de Pernambuco. Recife, PE, Brasil. | pt_BR |
| Subject | Zika virus infection | pt_BR |
| Subject | Zika virus | pt_BR |
| Subject | Microcephaly | pt_BR |
| Subject | Infant, newborn | pt_BR |
| Subject | Epidemiology | pt_BR |
| DeCS | Zika virus | pt_BR |
| DeCS | Infecção por Zika virus | pt_BR |
| DeCS | Microcefalia | pt_BR |
| DeCS | Recém-Nascido | pt_BR |
