In late 2019, a novel coronavirus (COVID-19) was identified in Wuhan, a city in the Hubei province of China. COVID-19 rapidly spread and led to an outbreak in China and then became a global health emergency. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2 or COVID-19), showed high transmission capacity and morbidity. In this way, WHO suggests that the most efficient method for controlling transmission is social isolation/quarantine to the population. Human and Swiss Webster Outbred stock, in both species we can define a distress intersection point: abrupt break in routine and compromise in social relationships. For this reason, we can observe in the Swiss Webster ethology various behavioral disturbances, such as family violence and aggression exacerbated. In this review, we hope, through comparative behavioral analysis, to avoid, mitigate and alleviate social stress in humans, mainly through procedures for raising animal welfare. In conclusion, we believed that our knowledge of Mouse Lab ethology can be useful, since, by minimizing stress, the most rudimentary emotions, similar between humans and mice, but concient-rationalized in the human and promote the improvement of the human being's elevated quality of life, even in social isolation/quarantine.