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Title: Extra-cellular matrix changes in Schistosoma mansoni-infected Biomphalaria glabrata
Authors: Borges, Claudia Maria da Cunha
Andrade, Zilton de Araújo
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.
Abstract: Reactivity of snails against parasites exhibits a primitive focal reaction, with encapsulation, phagocytosis and destruction of parasite larvae by macrophage-like cells - the hemocytes. This reaction mimics granulomatous inflammation seen in higher animals. However, different from the latter, little is known about the participation of extra-cellular matrix in such snail defense reactions. Normal and Schistosoma mansoni-infected Biomphalaria glabrata of different strains were submitted to cytological, histological, ultrastructural and biochemical methods in order to investigate the behavior of extra-cellular tissues at the site of anti-parasite reactions. In spite of the presence of two cell-types in peripheral hemolymph, only one cell-type was present at the sites of tissue reactions. Although pre-existent collagen and elastic fibers and microfibrils sometimes appeared slightly compressed around focal reactions, no evidences of duplication, synthesis or deposition of connective-tissue extra-cellular components were observed within or around the zones of reactive cell accumulations. Thus, tissue reactions against S. mansoni in the snail B. glabrata appeared exclusively dependent on one specific population of hemocytes.
Keywords: Biomphalaria glabrata
Schistosoma mansoni
Encapsulating complexes
Extra-cellular matrix
DeCS: Biomphalaria/parasitologia
Células do Tecido Conjuntivo/parasitologia
Matriz Extracelular/parasitologia
Schistosoma mansoni/patogenicidade
Issue Date: 2003
Citation: BORGES, C. M.; ANDRADE, Z. A. Extra-cellular matrix changes in Schistosoma mansoni-infected Biomphalaria glabrata. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 98, n. 1, p. 135-9, Jan. 2003.
Date of defense: 2003
Place of defense: Salvador
Defense institution: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz
ISSN: 0074-0276
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos
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