| Author | Almeida, Marcos Célio de | |
| Author | Cardoso, Silvia Andrade | |
| Author | Barral Netto, Manoel | |
| Access date | 2012-07-13T20:02:37Z | |
| Available date | 2012-07-13T20:02:37Z | |
| Document date | 2003 | |
| Citation | DE ALMEIDA, M.C.; CARDOSO, S.A.; BARRAL-NETTO, M. Leishmania (Leishmania) chagasi infection alters the expression of cell adhesion and costimulatory molecules on human monocyte and macrophage. International Journal of Parasitology, v. 33, n. 2, p. 153-62, feb. 2003. | pt_BR |
| ISSN | 0020-7519 | |
| ISSN | doi:10 . 10 1 6/S0 0 20 -7 51 9 (0 2) 00 2 66 -7 | |
| URI | https://www.arca.fiocruz.br/handle/icict/4163 | |
| Language | eng | pt_BR |
| Rights | open access | pt_BR |
| Title | Leishmania (Leishmania) chagasi infection alters the expression of cell adhesion and costimulatory molecules on human monocyte and macrophage. | pt_BR |
| Type | Article | pt_BR |
| Defense date | 2003 | |
| Departament | Centro de Pesquisas Gonçalo Moniz | pt_BR |
| Defense Institution | Fundação Oswaldo Cruz | pt_BR |
| Place of Defense | Salvador | pt_BR |
| Abstract | The initial steps of Leishmania infection in humans are largely unknown. There is limited information on the Leishmania infected human monocytes, the first cells that the parasite lives in, particularly related to costimulatory molecules. We show here that Leishmania (L.) chagasi infection avoids inducing proinflammatory molecules and has striking down modulating effects on human monocytes or macrophages. It does not induce CD54, interleukin (IL)-12 or tumour necrosis factor-alpha, potent proinflammatory cytokines and down modulates CD11b expression in monocytes. Lipopolysaccharide stimulated IL-12 (p40) levels, CD54 and HLA-DR expression are diminished in infected monocytes as well as interferon-gamma stimulated HLA-DR and HLA-ABC expression in infected macrophages. There is a negative correlation between CD54 and CD86 expression in both monocytes and macrophages. The depressed expression of class I and II molecules, absence of key proinflammatory cytokines and impaired expression of costimulatory molecules induced by L. chagasi could leave the immune system, at least in its initial phases in anergy or ignorance. | pt_BR |
| Affilliation | Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Subject | Costimulation | pt_BR |
| Subject | CD54 | pt_BR |
| Subject | CD11b | pt_BR |
| Subject | CD86 | pt_BR |
| Subject | Cytokines | pt_BR |
| Subject | Leishmania | pt_BR |
| xmlui.metadata.dc.title.original | Leishmania (Leishmania) chagasi infection alters the expression of cell adhesion and costimulatory molecules on human monocyte and macrophage. | pt_BR |
| DeCS | Antígenos CD80/metabolismo | pt_BR |
| DeCS | Leishmania infantum/patogenicidade | pt_BR |
| DeCS | Leishmaniose Visceral/imunologia | pt_BR |
| DeCS | Leishmaniose Visceral/parasitologia | pt_BR |
| DeCS | Macrófagos/parasitologia | pt_BR |
| DeCS | Monócitos/parasitologia | pt_BR |
| DeCS | Antígenos CD/imunologia | pt_BR |
| DeCS | Antígenos CD11b/imunologia | pt_BR |
| DeCS | Antígenos CD86 | pt_BR |
| DeCS | Adesão Celular | pt_BR |
| DeCS | Células Cultivadas | pt_BR |
| DeCS | Citocinas/imunologia | pt_BR |
| DeCS | Regulação para Baixo | pt_BR |
| DeCS | Citometria de Fluxo | pt_BR |
| DeCS | Antígenos HLA/imunologia | pt_BR |
| DeCS | Molécula 1 de Adesão Intercelular/imunologia | pt_BR |
| DeCS | Interferon gama/farmacologia | pt_BR |
| DeCS | Lipopolissacarídeos/farmacologia | pt_BR |
| DeCS | Ativação Linfocitária | pt_BR |
| DeCS | Macrófagos/imunologia | pt_BR |
