Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/4163
Title: Leishmania (Leishmania) chagasi infection alters the expression of cell adhesion and costimulatory molecules on human monocyte and macrophage.
Other Titles: Leishmania (Leishmania) chagasi infection alters the expression of cell adhesion and costimulatory molecules on human monocyte and macrophage.
Authors: Almeida, Marcos Célio de
Cardoso, Silvia Andrade
Barral Netto, Manoel
Affilliation: Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.
Abstract: The initial steps of Leishmania infection in humans are largely unknown. There is limited information on the Leishmania infected human monocytes, the first cells that the parasite lives in, particularly related to costimulatory molecules. We show here that Leishmania (L.) chagasi infection avoids inducing proinflammatory molecules and has striking down modulating effects on human monocytes or macrophages. It does not induce CD54, interleukin (IL)-12 or tumour necrosis factor-alpha, potent proinflammatory cytokines and down modulates CD11b expression in monocytes. Lipopolysaccharide stimulated IL-12 (p40) levels, CD54 and HLA-DR expression are diminished in infected monocytes as well as interferon-gamma stimulated HLA-DR and HLA-ABC expression in infected macrophages. There is a negative correlation between CD54 and CD86 expression in both monocytes and macrophages. The depressed expression of class I and II molecules, absence of key proinflammatory cytokines and impaired expression of costimulatory molecules induced by L. chagasi could leave the immune system, at least in its initial phases in anergy or ignorance.
Keywords: Costimulation
CD54
CD11b
CD86
Cytokines
Leishmania
DeCS: Antígenos CD80/metabolismo
Leishmania infantum/patogenicidade
Leishmaniose Visceral/imunologia
Leishmaniose Visceral/parasitologia
Macrófagos/parasitologia
Monócitos/parasitologia
Antígenos CD/imunologia
Antígenos CD11b/imunologia
Antígenos CD86
Adesão Celular
Células Cultivadas
Citocinas/imunologia
Regulação para Baixo
Citometria de Fluxo
Antígenos HLA/imunologia
Molécula 1 de Adesão Intercelular/imunologia
Interferon gama/farmacologia
Lipopolissacarídeos/farmacologia
Ativação Linfocitária
Macrófagos/imunologia
Issue Date: 2003
Citation: DE ALMEIDA, M.C.; CARDOSO, S.A.; BARRAL-NETTO, M. Leishmania (Leishmania) chagasi infection alters the expression of cell adhesion and costimulatory molecules on human monocyte and macrophage. International Journal of Parasitology, v. 33, n. 2, p. 153-62, feb. 2003.
Date of defense: 2003
Place of defense: Salvador
Department: Centro de Pesquisas Gonçalo Moniz
Defense institution: Fundação Oswaldo Cruz
ISSN: 0020-7519
doi:10 . 10 1 6/S0 0 20 -7 51 9 (0 2) 00 2 66 -7
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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