Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/4177
Title: Prevention of Haemophilus influenzae type b (Hib) meningitis and emergence of serotype replacement with type a strains after introduction of Hib immunization in Brazil.
Other Titles: Prevention of Haemophilus influenzae type b (Hib) meningitis and emergence of serotype replacement with type a strains after introduction of Hib immunization in Brazil.
Authors: Ribeiro, Guilherme de Sousa
Reis, Joice Neves
Cordeiro, Soraia Machado
Lima, Josilene Borges T
Gouveia, Edilane Lins
Petersen, Maya L
Salgado, Kátia M
Silva, Hagamenon R
Zanella, Rosemeire Cobo
Almeida, Samanta C. Grassi
Brandileone, Maria Cristina
Reis, Mitermayer Galvão dos
Ko, Albert Icksang
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.
University of California. School of Public Health. Berkeley, USA.
Hospital Couto Maia. Secretary of Health. Salvador, BA, Brasil.
Hospital Couto Maia. Secretary of Health. Salvador, BA, Brasil.
Adolfo Lutz Institute. Secretary of Health. São Paulo, SP, Brasil.
Adolfo Lutz Institute. Secretary of Health. São Paulo, SP, Brasil.
Adolfo Lutz Institute. Secretary of Health. São Paulo, SP, Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.
Abstract: Surveillance for Haemophilus influenzae meningitis cases was performed in Salvador, Brazil, before and after introduction of H. influenzae type b (Hib) immunization. The incidence of Hib meningitis decreased 69% during the 1-year period after initiation of Hib immunization (from 2.62 to 0.81 cases/100,000 person-years; P<.001). In contrast, the incidence for H. influenzae type a meningitis increased 8-fold (from 0.02 to 0.16 cases/100,000 person-years; P=.008). Pulsed-field gel electrophoretic analysis demonstrated that H. influenzae type a isolates belonged to 2 clonally related groups, both of which were found before Hib immunization commenced. Therefore, Hib immunization contributed to an increased risk for H. influenzae type a meningitis through selection of circulating H. influenzae type a clones. The risk attributable to serotype replacement is small in comparison to the large reduction in Hib meningitis due to immunization. However, these findings highlight the need to maintain surveillance as the use of conjugate vaccines expands worldwide.
DeCS: Vacinas Anti-Haemophilus/imunologia
Haemophilus influenzae tipo b/classificação
Haemophilus influenzae/classificação
Meningite por Haemophilus/prevenção & controle
Polissacarídeos Bacterianos/imunologia
Capsulas Bacterianas
Criança
Haemophilus influenzae/patogenicidade
Imunização
Lactente
Meningite por Haemophilus/microbiologia
Sorotipagem
Virulência
Issue Date: 2003
Citation: RIBEIRO, G.S. et al. Prevention of Haemophilus influenzae type b (Hib) meningitis and emergence of serotype replacement with type a strains after introduction of Hib immunization in Brazil. Journal of Infectious Disease, v. 187, n. 1, p. 109-16, jan. 2003.
Date of defense: 2003
Place of defense: Salvador
Department: Centro de Pesquisas Gonçalo Moniz
Defense institution: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz
ISSN: 0022-1899
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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