Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/4178
Title: Human study and experimental behavior of Schistosoma mansoni isolates from patients with different clinical forms of schistosomiasis
Authors: Conceição, Maria José
Lenzi, Henrique Leonel
Coura, José Rodrigues
Affilliation: Universidade Federal do Rio de Janeiro. Hospital Clementino Fraga Filho. Departamento de Medicina Preventiva. Pós-Graduação em Doenças Infecciosas e Parasitárias. Rio de Janeiro, RJ, Brasil /Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Doenças Infecciosas. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Doenças Infecciosas. Rio de Janeiro, RJ, Brasil.
Abstract: Twenty Schistosoma mansoni strains were isolated from three groups of patients (intestinal, hepatointestinal and hepatosplenic clinical forms) born and living in the town of Capitão Andrade, Minas Gerais, Brazil. Schistosomal isolate from each group was inoculated into three sets of mice with 25, 50 and 100 cercariae. The animals were killed 90 and 180 days after infection and submitted to extensive histopathological study of the liver, lung, intestine and spleen to determine qualitative and quantitative morphological characteristics, mainly of the granulomas. The histopathological changes caused the same patterns of infection in mice and were proportional to the inoculum and the time of infection, confirming the relevance of quantitative aspects in the determination of the disease. These data indicate three possibilities: (1) mouse model is not adequate to predict possible differences in the S. mansoni isolates obtained from patients; (2) field isolates are probably genetic polymorphic and undifferentiated; (3) schistosomiasis in human does not depend on parasite intrinsic factors, but on multivariable factors, such as intensity and duration of infection, time of infection, age and gender and other characteristics such as host response.
Keywords: Schistosoma mansoni
Clinical forms
Strain
Parasite burden
Isolates
Granuloma
DeCS: Schistosoma mansoni, patologia
Granuloma, parasitologia
Variação Genética
Granuloma, patologia
Intestinos, patologia
Baço, patologia
Schistosoma mansoni, parasitologia
Baço, parasitologia
Issue Date: 2008
Publisher: Elsevier
Citation: CONCEIÇÃO, M. J.; LENZI, H. L.; COURA, J. R. Human study and experimental behavior of Schistosoma mansoni isolates from patients with different clinical forms of schistosomiasis. Acta Tropica, v.108, n.2-3, Nov.-Dec., 2008.
DOI: http://dx.doi.org/10.1016/j.actatropica.2008.05.007
ISSN: 0001-706X
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos

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