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Sustainable Development Goals
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PSYCHO-NEUROENDOCRINE-IMMUNE INTERACTIONS IN COVID-19: POTENTIAL IMPACTS ON MENTAL HEALTH
Sistema nervoso central
Citocinas
Saúde mental
Pandemia
SARS-CoV-2
Isolamento social
COVID-19
HPA axis
Cytokines
Mental health
Pandemic
SARS-CoV-2
Social isolation
Author
Affilliation
Abstract
Coronavirus disease 2019 (COVID-19) is caused by the Severe Acute Respiratory
Syndrome Coronavirus 2 (SARS-CoV-2). The impacts of the disease may be beyond
the respiratory system, also affecting mental health. Several factors may be involved
in the association between COVID-19 and psychiatric outcomes, such as fear inherent
in the pandemic, adverse effects of treatments, as well as financial stress, and social
isolation. Herein we discuss the growing evidence suggesting that the relationship
between SARS-CoV-2 and host may also trigger changes in brain and behavior. Based
on the similarity of SARS-CoV-2 with other coronaviruses, it is conceivable that changes
in endocrine and immune response in the periphery or in the central nervous system
may be involved in the association between SARS-CoV-2 infection and impaired mental
health. This is likely to be further enhanced, since millions of people worldwide are
isolated in quarantine to minimize the transmission of SARS-CoV-2 and social isolation
can also lead to neuroendocrine-immune changes. Accordingly, we highlight here
the hypothesis that neuroendocrine-immune interactions may be involved in negative
impacts of SARS-CoV-2 infection and social isolation on psychiatric issues.
Keywords in Portuguese
COVID-19Sistema nervoso central
Citocinas
Saúde mental
Pandemia
SARS-CoV-2
Isolamento social
Keywords
Central nervous systemCOVID-19
HPA axis
Cytokines
Mental health
Pandemic
SARS-CoV-2
Social isolation
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