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https://www.arca.fiocruz.br/handle/icict/41946
CLINICOPATHOLOGICAL ASPECTS AND PROVIRAL LOAD OF ADULTHOOD INFECTIVE DERMATITIS ASSOCIATED WITH HTLV-1: COMPARISON BETWEEN JUVENILE AND ADULTHOOD FORMS
Author
Affilliation
Federal University of Bahia. Faculty of Medicine. Salvador, BA, Brazil.
Federal University of Bahia. Professor Edgard Santos Teaching Hospital. Department of Dermatology. Salvador, BA, Brazil.
Federal University of Bahia. Professor Edgard Santos Teaching Hospital. Department of Dermatology. Salvador, BA, Brazil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil / Catalan Institute of Oncology. Bellvitge Biomedical Research Institute. l’Hospitalet de Llobregat. Barcelona, Catalonia, Spain.
Federal University of Bahia. Professor Edgard Santos Teaching Hospital. Department of Pathology. Salvador, BA, Brasil.
Federal University of Bahia. Professor Edgard Santos Teaching Hospital. Department of Dermatology. Salvador, BA, Brazil.
Federal University of Bahia. Professor Edgard Santos Teaching Hospital. Department of Dermatology. Salvador, BA, Brazil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil / Catalan Institute of Oncology. Bellvitge Biomedical Research Institute. l’Hospitalet de Llobregat. Barcelona, Catalonia, Spain.
Federal University of Bahia. Professor Edgard Santos Teaching Hospital. Department of Pathology. Salvador, BA, Brasil.
Abstract
Infective dermatitis associated with human T-cell lymphotropic virus type-1 (HTLV-1), (IDH), is a chronic eczema occurring in HTLV-1 infected children. Rare cases of adulthood IDH have been reported and no study until now aimed to compare juvenile and adulthood IDH. Methodology/Principal findings
Twelve cases of adulthood IDH followed for a mean time of 7.5 years were analyzed according
to clinicopathological and molecular aspects, comparing them to juvenile IDH cases.
Diagnosis was based on the modified major criteria used for juvenile IDH. Proviral load
(PVL) assessment was performed by real-time PCR technique. Adulthood IDH presented
similar clinicopathological and molecular aspects compared to juvenile IDH. The morphology
of lesions and areas of involvement were similar, except for the involvement of the
ankles and inframammary folds in the adulthood form. HTLV-1 associated myelopathy/tropical
spastic paraparesis (HAM/TSP) occurred in six adulthood IDH patients, with almost
equal frequency. However, at least in two patients, HAM/TSP appeared prior to IDH, differently
from what was observed in juvenile IDH.
Conclusions/Significance
Adulthood IDH is similar to juvenile IDH according to clinicopathological aspects and PVL
levels. Therefore, the same modified major diagnostic criteria for juvenile IDH can be applied
to both forms.
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