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Title: Pathology of Intracardiac Nerves in Experimental Chagas Disease
Authors: Ribeiro, Lídia Cristina Villela
Barbosa Junior, Aryon de Almeida
Andrade, Zilton de Araújo
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Abstract: Severe destruction of intrinsic cardiac nerves has been reported in experimental acute Chagas myocarditis, followed by extensive regeneration during the chronic phase of the infection. To further study this subject, the sympathetic and para-sympathetic intracardiac nerves of mice infected with a virulent Trypanosoma cruzi strain were analyzed, during acute and chronic infection, by means of histological, histochemical, morphometric and electron microscopic techniques. No evidences of destructive changes were apparent. Histochemical demonstration for acetylcholinesterase and catecholamines did not reveal differences in the amount and distribution of intracardiac nerves, in mice with acute and chronic Chagas myocarditis or in non-infected controls. Mild, probably reversible ultrastructural neural changes were occasionally present, especially during acute myocarditis. Intrinsic nerves appeared as the least involved cardiac structure during the course of experimental Chagas disease in mice.
Keywords: intracardiac nerves
Trypanosoma cruzi
Chagas disease
DeCS: Cardiomiopatia Chagásica/patologia
Fibras Nervosas/patologia
Doença Aguda
Doença Crônica
Modelos Animais de Doenças
Microscopia Eletrônica
Fibras Nervosas/ultraestrutura
Estatísticas não Paramétricas
Issue Date: 2002
Citation: RIBEIRO, L.C.; BARBOSA, A.A.; ANDRADE, Z.A. Pathology of intracardiac nerves in experimental Chagas disease. Memórias do Instituto Oswaldo Cruz, v. 97, n. 7, p. 1019-25, oct. 2002.
ISSN: 0074-0276
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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