Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/4223
Title: Experimental neuroschistosomiasis: inadequacy of the murine model.
Authors: Silva, Luciana Menezes da
Oliveira, Carla Neves de
Andrade, Zilton de Araújo
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Abstract: Neuroschistosomiasis is rarely observed in human pathology, but it is of considerable importance. To investigate its pathogenesis, consequences and response to treatment, an experimental model would be desirable, but is not yet available, in spite of a few indications of a suitable mouse model in the literature. Severe, recent and late Schistosoma mansoni infections in outbred and inbred strains of mice revealed widespread distribution of parasite eggs in several organs, but only exceptionally did eggs reach the encephalus, thus revealing the inadequacy of the mouse as an experimental model for neuroschistosomiasis.
Keywords: Neuroschistosomiasis
Schistosoma mansoni
Murine model
DeCS: Encéfalo/parasitologia
Modelos Animais de Doenças
Neuroesquistossomose
Animais
Masculino
Feminino
Camundongos
Camundongos Endogâmicos BALB C
Camundongos Endogâmicos C57BL
Contagem de Ovos de Parasitas
Issue Date: 2002
Citation: SILVA, L.M.; OLIVEIRA, C.N.; ANDRADE, Z.A. Experimental neuroschistosomiasis: inadequacy of the murine model. Memórias do Instituto Oswaldo Cruz, v. 97, n. 4, p. 599-600, jun. 2002.
ISSN: 0074-0276
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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