| Author | Maya-Monteiro, Clarissa M. | |
| Author | Silva, Felipe Corrêa da | |
| Author | Hofmann, Sussana S. | |
| Author | Hesselink, Matthijs K. C. | |
| Author | la Fleur, Sussanne E. | |
| Author | Yi, Chun-Xia | |
| Access date | 2020-07-31T19:24:02Z | |
| Available date | 2020-07-31T19:24:02Z | |
| Document date | 2020 | |
| Citation | MAYA-MONTEIRO, Clarissa M. et al. Lipid Droplets accumulate in the hypothalamus of mice and humans with and without metabolic diseases. Neuro-endocrinology, p. 1-41, May 2020. | pt_BR |
| ISSN | 0028-3835 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/42494 | |
| Language | eng | pt_BR |
| Publisher | Karger Publishers | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Cérebro | pt_BR |
| Subject in Portuguese | Gotícula lipídica | pt_BR |
| Subject in Portuguese | Hipotálamo | pt_BR |
| Subject in Portuguese | Resistência à insulina | pt_BR |
| Subject in Portuguese | Tipo 2 Diabestes Mellitus | pt_BR |
| Title | Lipid Droplets accumulate in the hypothalamus of mice and humans with and without metabolic diseases | pt_BR |
| Type | Article | |
| DOI | 10.1159/000508735 | pt_BR |
| Abstract | In peripheral tissues, the lipid droplet (LD) organelle links lipid metabolism,
inflammation and insulin resistance. Little is known about the brain LDs. Objectives: We
hypothesised that hypothalamic LDs would be altered in metabolic diseases. Methods: We
used immunofluorescence for the specific LD protein, PLIN2, as the marker to visualize and
quantify LDs. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / Laboratory of Endocrinology and Department of Endocrinology and Metabolism, Amsterdam Neuroscience, Amsterdam University Medical Centers (UMC), University of Amsterdam, Amsterdam, the Netherlands / Netherlands Institute for Neuroscience, an Institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, the Netherlands. | pt_BR |
| Affilliation | Laboratory of Endocrinology and Department of Endocrinology and Metabolism, Amsterdam Neuroscience, Amsterdam University Medical Centers (UMC), University of Amsterdam, Amsterdam, the Netherlands. | pt_BR |
| Affilliation | Institute for Diabetes and Regeneration, Helmholtz Diabetes Center, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany. | pt_BR |
| Affilliation | Department of Nutrition and Movement Sciences. Maastricht University Medical Centre+ and NUTRIM School for Nutrition and Translational Research in Metabolism. Maastricht, the Netherlands | pt_BR |
| Affilliation | Laboratory of Endocrinology and Department of Endocrinology and Metabolism, Amsterdam Neuroscience, Amsterdam University Medical Centers (UMC), University of Amsterdam, Amsterdam, the Netherlands / Netherlands Institute for Neuroscience, an Institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, the Netherlands. | pt_BR |
| Affilliation | Laboratory of Endocrinology and Department of Endocrinology and Metabolism, Amsterdam Neuroscience, Amsterdam University Medical Centers (UMC), University of Amsterdam, Amsterdam, the Netherlands. | pt_BR |
| Subject | Brain | pt_BR |
| Subject | Lipid droplet | pt_BR |
| Subject | Hypothalamus | pt_BR |
| Subject | Insulin resistance | pt_BR |
| Subject | PLIN2 | pt_BR |
| Subject | Type 2 Diabestes Mellitus | pt_BR |
| e-ISSN | 1423-0194 | |
