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LIPID DROPLETS ACCUMULATE IN THE HYPOTHALAMUS OF MICE AND HUMANS WITH AND WITHOUT METABOLIC DISEASES
Maya-Monteiro, Clarissa M. et al. | Date Issued: 2020
Author
Maya-Monteiro, Clarissa M.
Silva, Felipe Corrêa da
Hofmann, Sussana S.
Hesselink, Matthijs K. C.
la Fleur, Sussanne E.
Yi, Chun-Xia
Affilliation
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / Laboratory of Endocrinology and Department of Endocrinology and Metabolism, Amsterdam Neuroscience, Amsterdam University Medical Centers (UMC), University of Amsterdam, Amsterdam, the Netherlands / Netherlands Institute for Neuroscience, an Institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, the Netherlands.
Laboratory of Endocrinology and Department of Endocrinology and Metabolism, Amsterdam Neuroscience, Amsterdam University Medical Centers (UMC), University of Amsterdam, Amsterdam, the Netherlands.
Institute for Diabetes and Regeneration, Helmholtz Diabetes Center, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany.
Department of Nutrition and Movement Sciences. Maastricht University Medical Centre+ and NUTRIM School for Nutrition and Translational Research in Metabolism. Maastricht, the Netherlands
Laboratory of Endocrinology and Department of Endocrinology and Metabolism, Amsterdam Neuroscience, Amsterdam University Medical Centers (UMC), University of Amsterdam, Amsterdam, the Netherlands / Netherlands Institute for Neuroscience, an Institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, the Netherlands.
Laboratory of Endocrinology and Department of Endocrinology and Metabolism, Amsterdam Neuroscience, Amsterdam University Medical Centers (UMC), University of Amsterdam, Amsterdam, the Netherlands.
Abstract
In peripheral tissues, the lipid droplet (LD) organelle links lipid metabolism, inflammation and insulin resistance. Little is known about the brain LDs. Objectives: We hypothesised that hypothalamic LDs would be altered in metabolic diseases. Methods: We used immunofluorescence for the specific LD protein, PLIN2, as the marker to visualize and quantify LDs.
Keywords in Portuguese
Cérebro
Gotícula lipídica
Hipotálamo
Resistência à insulina
Tipo 2 Diabestes Mellitus
 
Keywords
Brain
Lipid droplet
Hypothalamus
Insulin resistance
PLIN2
Type 2 Diabestes Mellitus
 
Publisher
Karger Publishers
Citation
MAYA-MONTEIRO, Clarissa M. et al. Lipid Droplets accumulate in the hypothalamus of mice and humans with and without metabolic diseases. Neuro-endocrinology, p. 1-41, May 2020.
DOI
10.1159/000508735
ISSN
0028-3835