Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/42494
Title: Lipid Droplets accumulate in the hypothalamus of mice and humans with and without metabolic diseases
Authors: Maya-Monteiro, Clarissa M.
Silva, Felipe Corrêa da
Hofmann, Sussana S.
Hesselink, Matthijs K. C.
la Fleur, Sussanne E.
Yi, Chun-Xia
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / Laboratory of Endocrinology and Department of Endocrinology and Metabolism, Amsterdam Neuroscience, Amsterdam University Medical Centers (UMC), University of Amsterdam, Amsterdam, the Netherlands / Netherlands Institute for Neuroscience, an Institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, the Netherlands.
Laboratory of Endocrinology and Department of Endocrinology and Metabolism, Amsterdam Neuroscience, Amsterdam University Medical Centers (UMC), University of Amsterdam, Amsterdam, the Netherlands.
Institute for Diabetes and Regeneration, Helmholtz Diabetes Center, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany.
Department of Nutrition and Movement Sciences. Maastricht University Medical Centre+ and NUTRIM School for Nutrition and Translational Research in Metabolism. Maastricht, the Netherlands
Laboratory of Endocrinology and Department of Endocrinology and Metabolism, Amsterdam Neuroscience, Amsterdam University Medical Centers (UMC), University of Amsterdam, Amsterdam, the Netherlands / Netherlands Institute for Neuroscience, an Institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, the Netherlands.
Laboratory of Endocrinology and Department of Endocrinology and Metabolism, Amsterdam Neuroscience, Amsterdam University Medical Centers (UMC), University of Amsterdam, Amsterdam, the Netherlands.
Abstract: In peripheral tissues, the lipid droplet (LD) organelle links lipid metabolism, inflammation and insulin resistance. Little is known about the brain LDs. Objectives: We hypothesised that hypothalamic LDs would be altered in metabolic diseases. Methods: We used immunofluorescence for the specific LD protein, PLIN2, as the marker to visualize and quantify LDs.
Keywords: Brain
Lipid droplet
Hypothalamus
Insulin resistance
PLIN2
Type 2 Diabestes Mellitus
keywords: Cérebro
Gotícula lipídica
Hipotálamo
Resistência à insulina
Tipo 2 Diabestes Mellitus
Issue Date: 2020
Publisher: Karger Publishers
Citation: MAYA-MONTEIRO, Clarissa M. et al. Lipid Droplets accumulate in the hypothalamus of mice and humans with and without metabolic diseases. Neuro-endocrinology, 41p, online May 2020.
ISSN: 0028-3835
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos

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