Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/42501
Title: Haem oxygenase protects against thrombocytopaenia and malaria-associated lung injury
Authors: Quintanilha, Isaclaudia G. de Azevedo
Moraes, Isabel M. Medeiros de
Ferreira, André C.
Reis, Patrícia A.
Abreu, Adriana Vieira de
Campbell, Robert A.
Weyrich, Andrew S.
Bozza, Patricia T.
Zimmerman, Guy A.
Faria Neto, Hugo C. Castro
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / Universidade Iguaçu. Nova Iguaçu, RJ, Brasil.
University of Utah School of Medicine. Division of Endocrinology, Metabolism, and Diabetes. Salt Lake City, UT, USA.
University of Utah. Department of Internal Medicine and Program in Molecular Medicine. Salt Lake City, UT, USA.
University of Utah. Department of Internal Medicine and Program in Molecular Medicine. Salt Lake City, UT, USA.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.
University of Utah. Department of Internal Medicine and Program in Molecular Medicine. Salt Lake City, UT, USA.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.
Abstract: Malaria-triggered lung injury can occur in both severe and non-severe cases. Platelets may interact with parasitized erythrocytes, leukocytes and endothelium. These interactions can lead to microvessel obstructions and induce release of inflammatory mediators. Induction of the haem oxygenase enzyme is important in the host's response to free haem and to several other molecules generated by infectious or non-infectious diseases. In addition, an important role for the haem oxygenase-1 isotype has been demonstrated in experimental cerebral malaria and in clinical cases. Therefore, the present work aims to determine the influence of haem oxygenase in thrombocytopaenia and acute pulmonary injury during infection with Plasmodium berghei strain NK65.
Keywords: Acute lung injury
Acute respiratory distress syndrome
Infammation
Malaria
Platelets
Heme oxygenase
keywords: Lesão pulmonar aguda
Síndrome do desconforto respiratório agudo
Inflamação
Malária
Plaquetas
Heme oxygenase
DeCS: Heme Oxigenase (Desciclizante)
Issue Date: 2020
Publisher: BMC
Citation: QUINTANILHA, Isaclaudia G. de Azevedo et al. Haem oxygenase protects against thrombocytopaenia and malaria‑associated lung injury. Malaria Journal, v. 19, n. 234, p. 1-16, 2020.
DOI: 10.1186/s12936-020-03305-6
ISSN: 1475-2875
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos

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