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AutorSantiago, Paula Beatriz
AutorAraújo, Carla Nunes de
AutorCharneau, Sébastien
AutorBastos, Izabela Marques Dourado
AutorAssumpção, Teresa Cristina F.
AutorQueiroz, Rayner Myr Lauterjung
AutorPraça, Yanna Reis
AutorCordeiro, Thuany de Moura
AutorGarcia, Carlos Henrique Saraiva
AutorSilva, Ionizete Garcia da
AutorRaiol, Tainá
AutorMotta, Flávia Nader
AutorOliveira, João Victor de Araújo
AutorSousa, Marcelo Valle de
AutorRibeiro, José Marcos C.
AutorSantana, Jaime Martins de
Fecha de acceso2020-08-12T12:30:57Z
Fecha de disponibilización2020-08-12T12:30:57Z
Fecha de publicación2018
ReferenciaSANTIAGO, Paula Beatriz et al. Exploring the molecular complexity of Triatoma dimidiata sialome. Journal of Proteomics, [s.l.], v. 174, p.47-60, 2018.pt_BR
ISSN1876-7737pt_BR
URIhttps://www.arca.fiocruz.br/handle/icict/42702
DescripciónTainá Raiol - Fundação Oswaldo Cruz. Fiocruz Brasília. Brasília, DF, Brasil. Documento produzido em parceria ou por autor vinculado em mais de uma unidade da Fiocruz, mas não consta à informação no documento do vinculo com a Fiocruz Brasília.pt_BR
Idiomaengpt_BR
EditorElsevierpt_BR
Derechos de autorrestricted accesspt_BR
MeSHAnimalspt_BR
MeSHChagas Diseasept_BR
MeSHHigh-Throughput Nucleotide Sequencingpt_BR
MeSHHumanspt_BR
MeSHInsect Vectorspt_BR
MeSHSalivary Glandspt_BR
MeSHTranscriptomept_BR
MeSHTriatomapt_BR
TítuloExploring the molecular complexity of Triatoma dimidiata sialomept_BR
Tipo del documentoArticle
DOI10.1016/j.jprot.2017.12.016
Resumen en InglésTriatoma dimidiata, a Chagas disease vector widely distributed along Central America, has great capability for domestic adaptation as the majority of specimens caught inside human dwellings or in peridomestic areas fed human blood. Exploring the salivary compounds that overcome host haemostatic and immune responses is of great scientific interest. Here, we provide a deeper insight into its salivary gland molecules. We used high-throughput RNA sequencing to examine in depth the T. dimidiata salivary gland transcriptome. From >51 million reads assembled, 92.21% are related to putative secreted proteins. Lipocalin is the most abundant gene family, confirming it is an expanded family in Triatoma genus salivary repertoire. Other putatively secreted members include phosphatases, odorant binding protein, hemolysin, proteases, protease inhibitors, antigen-5 and antimicrobial peptides. This work expands the previous set of functionally annotated sequences from T. dimidiata salivary glands available in NCBI from 388 to 3815. Additionally, we complemented the salivary analysis through proteomics (available data via ProteomeXchange with identifier PXD008510), disclosing the set complexity of 119 secreted proteins and validating the transcriptomic results. Our large-scale approach enriches the pharmacologically active molecules database and improves our knowledge about the complexity of salivary compounds from haematophagous vectors and their biological interactions.pt_BR
AfiliaciónUniversity of Brasília. Faculty of Medicine. Programa Pós-Graduação em Ciências Médicas. Brasília, DF, Brazil.pt_BR
AfiliaciónUniversity of Brasília. Faculty of Medicine. Programa Pós-Graduação em Ciências Médicas. Brasília, DF, Brazil / University of Brasília. Faculty of Ceilândia. Brasília, DF, Brazil.pt_BR
AfiliaciónUniversity of Brasília. Department of Cell Biology. Brasília, DF, Brazil.pt_BR
AfiliaciónUniversity of Brasília. Department of Cell Biology. Brasília, DF, Brazil.pt_BR
AfiliaciónNational Institute of Allergy and Infectious Disease. Laboratory of Malaria and Vector Research. Vector Biology Section. Rockville, MD, United States.pt_BR
AfiliaciónUniversity of Brasília. Department of Cell Biology. Brasília, DF, Brazil.pt_BR
AfiliaciónUniversity of Brasília. Faculty of Medicine. Programa Pós-Graduação em Ciências Médicas. Brasília, DF, Brazil.pt_BR
AfiliaciónUniversity of Brasília. Department of Cell Biology. Brasília, DF, Brazil.pt_BR
AfiliaciónUniversity of Brasília. Department of Cell Biology. Brasília, DF, Brazil.pt_BR
AfiliaciónUniversity of Goiás. Department of Parasitology, Goiânia, GO, Brazil.pt_BR
AfiliaciónUniversity of Brasília. Department of Cell Biology. Brasília, DF, Brazil / Fundação Oswaldo Cruz. Fiocruz Amazônia. Instituto Leônidas e Maria Deane. Manaus, AM, Brazil.pt_BR
AfiliaciónUniversity of Brasília. Faculty of Ceilândia. Brasília, DF, Brazil.pt_BR
AfiliaciónUniversity of Brasília. Department of Computer Science. Brasília, DF, Brazil.pt_BR
AfiliaciónUniversity of Brasília. Department of Cell Biology. Brasília, DF, Brazil.pt_BR
AfiliaciónNational Institute of Allergy and Infectious Disease. Laboratory of Malaria and Vector Research. Vector Biology Section. Rockville, MD, United States.pt_BR
AfiliaciónUniversity of Brasília. Faculty of Medicine. Programa Pós-Graduação em Ciências Médicas. Brasília, DF, Brazil / University of Brasília. Department of Cell Biology. Brasília, DF, Brazil.pt_BR
Palavras clave en InglêsTriatoma dimidiatapt_BR
Palavras clave en InglêsTriatominaept_BR
Palavras clave en InglêsChagas diseasept_BR
Palavras clave en InglêsSialomept_BR
Palavras clave en InglêsHaematophagypt_BR
Palavras clave en InglêsVector biologypt_BR
DeCSDoença de Chagaspt_BR
DeCSSequenciamento de Nucleotídeos em Larga Escalapt_BR
DeCSInsetos Vetorespt_BR
DeCSGlândulas Salivarespt_BR
DeCSPerfilação da Expressão Gênicapt_BR
DeCSTriatomapt_BR
Fecha de embargo2022-12-31


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