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Sustainable Development Goals
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- IOC - Artigos de Periódicos [12980]
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APPLICATION OF WHO INTERNATIONAL BIOLOGICAL REFERENCE STANDARDS TO EVALUATE COMMERCIAL SEROLOGICAL TESTS FOR CHRONIC CHAGAS DISEASE
Doença de Chagas em humanos
Testes diagnósticos sorológicos
Imunoensaios
Normas Internacionais de Referência Biológica
Human Chagas disease
Serological diagnostic tests
Immunoassays
International Biological Reference Standards
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Abstract
Chagas disease, resulting from Trypanosoma cruzi infections, continues to be a health concern mainly in Latin
American countries where the parasite is endemic. The laboratory diagnosis of a chronic infection is determined through
serological assays for antibodies against T. cruzi and several tests are available that differ in key components, formats and
methodologies. To date, no single test meets the criteria of a gold standard. The situation is further complicated by the difficulties
associated with performance comparisons between different immunoassays or methodologies executed at different times and
geographical areas.
Keywords in Portuguese
Trypanosoma cruziDoença de Chagas em humanos
Testes diagnósticos sorológicos
Imunoensaios
Normas Internacionais de Referência Biológica
Keywords
Trypanosoma cruziHuman Chagas disease
Serological diagnostic tests
Immunoassays
International Biological Reference Standards
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