Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/43378
Title: Trypanosoma cruzi: experimental Chagas`Disease in Rhesus monkeys, II. Ultrastructural and cytochemical studies of Peroxidase and Acid Phosphatase activities
Authors: Meirelles, Maria de Nazareth Leal de
Almeida, Maria da Glória Bonecini
Pessoa, Maria Heleosina Ribeiro
Castro, Bernardo Galvão
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Ultraestrutura e Biologia Celular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. WHO Colaborating Center for Research and Training in Parasitic Disease. Rio de Janeiro, RJ, Brasil.
Universidade do Estado do Rio de Janeiro. Serviço de Microbiologia e Imunologia. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. WHO Colaborating Center for Research and Training in Parasitic Disease. Rio de Janeiro, RJ, Brasil.
Abstract: Ultrastructural and cytochemical studies of peroxidase and acid phosphatase were performed in skin, lymph node and heart muscle tissue of thesus monkeys with experimental Chagas's disease. At the site of inoculation ther was a proliferative reaction with the presence of immature macrophages revealed by peroxidase technique. At the lymph node a difuse inflammatory exudate with mononuclear cells, fibroblasts and immature activated macrophages reproduces the human patrtern of acute Chagas' disease inflamatory lesions. The hearth muscle cells present different degrees of degenerative alterations and a striking increase in the number of lysosomal profiles that exhibit acid hydrolase reaction product. A strong inflammatory reaction was present due to lymphocytic infiltrate or due to eosinophil granulocytes associated to ruptured cells. The present study provides some experimental evidences that the monkey model could be used as a reliable model to characterize histopathological alterations of the human disease.
Keywords: Ultrastructural cytochemistry
Peroxidase activity
Chagas Disease
Acid phosphatase
Rhesus monkeys
keywords: Doença de Chagas
Peroxidase atividade
Citoquímica ultraestrutural
Fosfatase ácida
Macacos rhesus
Issue Date: 1990
Publisher: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
Citation: MEIRELLES, Maria de Nazareth Leal de et al. Trypanosoma cruzi: experimental Chagas' disease in Rhesus monkeys. II. Ultraestructural and cytochemical studies of peroxidase and acid phosphatase activities. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 85, n. 2, p. 173-181, Apr./Aug. 1990.
DOI: 10.1590/S0074-02761990000200005
ISSN: 0074-0206
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos
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