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AutorDamasceno, Patricia Kauanna Fonseca
AutorSantana, Thaís Alves de
AutorSantos, Girlaine Café
AutorOrge, Iasmim Diniz
AutorSilva, Daniela Nascimento
AutorAlbuquerque, Juliana Fonseca
AutorGolinelli, Giulia
AutorGrisendi3, Giulia
AutorPinelli, Massimo
AutorSantos, Ricardo Ribeiro dos
AutorDominici, Massimo
AutorSoares, Milena Botelho Pereira
Fecha de acceso2020-09-16T14:48:32Z
Fecha de disponibilización2020-09-16T14:48:32Z
Fecha de publicación2020
ReferenciaDAMASCENO, Patricia Kauanna Fonseca et al. Kauanna FonsecaGenetic Engineering as a Strategy to Improve the Therapeutic Efficacy of Mesenchymal Stem/Stromal Cells in Regenerative Medicine. Frontiers in Cell and Developmental Biology, v. 8, Article 737, p. 1-24, Aug. 2020.pt_BR
ISSN2296-634Xpt_BR
URIhttps://www.arca.fiocruz.br/handle/icict/43400
PromociónBrazilian National Research Council (CNPq)/MS grant number 443909/2018-0 and INOVA/FIOCRUZ grant number VPPIS-001-FIO-18-70.pt_BR
Idiomaengpt_BR
EditorFrontiers Mediapt_BR
Derechos de autoropen accesspt_BR
Palabras clave en PortuguésCélulas-tronco mesenquimaispt_BR
Palabras clave en PortuguésEngenharia genéticapt_BR
Palabras clave en PortuguésMedicina regenerativapt_BR
Palabras clave en PortuguésTerapia celularpt_BR
Palabras clave en PortuguésTerapia de genespt_BR
Palabras clave en PortuguésCélulas estromaispt_BR
TítuloGenetic Engineering as a Strategy to Improve the Therapeutic Efficacy of Mesenchymal Stem/Stromal Cells in Regenerative Medicinept_BR
Tipo del documentoArticlept_BR
DOI10.3389/fcell.2020.00737pt_BR
Resumen en InglésMesenchymal stem/stromal cells (MSCs) have been widely studied in the field of regenerative medicine for applications in the treatment of several disease settings. The therapeutic potential of MSCs has been evaluated in studies in vitro and in vivo, especially based on their anti-inflammatory and pro-regenerative action, through the secretion of soluble mediators. In many cases, however, insufficient engraftment and limited beneficial effects of MSCs indicate the need of approaches to enhance their survival, migration and therapeutic potential. Genetic engineering emerges as a means to induce the expression of different proteins and soluble factors with a wide range of applications, such as growth factors, cytokines, chemokines, transcription factors, enzymes and microRNAs. Distinct strategies have been applied to induce genetic modifications with the goal to enhance the potential of MCSs. This review aims to contribute to the update of the different genetically engineered tools employed for MSCs modification, as well as the factors investigated in different fields in which genetically engineered MSCs have been tested.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Health Institute of Technology. Salvador, BA, Brazil.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Health Institute of Technology. Salvador, BA, Brazil.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Health Institute of Technology. Salvador, BA, Brazil.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.pt_BR
AfiliaciónUniversity of Modena and Reggio Emilia. Laboratory of Cellular Therapy. Division of Oncology. Modena, Italy.pt_BR
AfiliaciónUniversity of Modena and Reggio Emilia. Laboratory of Cellular Therapy. Division of Oncology. Modena, Italy.pt_BR
AfiliaciónUniversity of Modena and Reggio Emilia. Department of Medical and Surgical Sciences for Children & Adults. Division of Plastic Surgery. Modena, Italy.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Health Institute of Technology. Salvador, BA, Brazil / National Institute of Science and Technology for Regenerative Medicine. Rio de Janeiro, RJ, Brazil.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Health Institute of Technology. Salvador, BA, Brazil / National Institute of Science and Technology for Regenerative Medicine. Rio de Janeiro, RJ, Brazil.pt_BR
Palavras clave en InglêsMesenchymal stempt_BR
Palavras clave en InglêsGenetic engineeringpt_BR
Palavras clave en InglêsRegenerative medicinept_BR
Palavras clave en InglêsCell therapypt_BR
Palavras clave en InglêsGene therapypt_BR
Palavras clave en InglêsStromal cellspt_BR


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