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VACCINATION AGAINST SCHISTOSOMIASIS AND FASCIOLIASIS WITH THE NEW RECOMBINANT ANTIGEN SM14: POTENTIAL BASIS OF A MULTI-VALENT ANTI-HELMINTH VACCINE?
Tendler, Miriam et al. | Date Issued: 1995
Author
Tendler, Miriam
Vilar, Monica Magno
Brito, Cristiana Alves
Freire, Nicolau Maués da Serra
Katz, Naftale
Simpson, Andrew
Affilliation
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Helmintologia. Laboratõrio de Esquistossomose Experimental. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Helmintologia. Laboratõrio de Esquistossomose Experimental. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou, Laboratório de Biologia Molecular. Belo Horizonte, MG, Brasil.
Universidade Federal Rural do Rio de Janeiro. Seropédica, RJ, Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou, Laboratório de Biologia Molecular. Belo Horizonte, MG, Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou, Laboratório de Biologia Molecular. Belo Horizonte, MG, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou, Laboratório de Esquistossomose. Belo Horizonte. MG, Brasil.
Abstract
Molecular cloning of components of protective antigenic preparations have suggested that related parasite fatty acid binding proteins could form the basis of the well documented protective, immune cross reactivity between the parasitic trematode worms Fasciola hepatica and Schistosoma mansoni. We have now confirmed the cross protective potential of parasite fatty acid binding proteins and suggest that it may be possible to produce a single vaccine that would be effective against at least two parasites, F. hepatica and S. mansoni of veterinary and human importance respectively.
Keywords in Portuguese
Esquistossomose
Fascioliasis
Vacinas
Proteína de ligação de ácido graxo
 
Keywords
Schistosomiasis
Fascioliasis
Vaccines
Fatty acid binding protein
 
Publisher
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
Citation
TENDLER, Miriam et al. Vaccination against schistosomiasis and fascioliasis with the new recombinant antigen Sm14: potential basis of a multi-valent anti-helminth vaccine?. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 90, n. 2, p. 255-256, Mar./Apr. 1995.
DOI
10.1590/S0074-02761995000200022
ISSN
0074-0276