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THE GROWTH OF BROWN ADIPOSE TISSUE IN COLD-ACCLIMATIZED RATS AFTER DEPLETION OF MAST CELL HISTAMINE BY COMPOUND 48/80
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Universidad Centroccidental Lisandro Alvarado. Escuela de Ciencias Veterinarias. Unidad de Investigación en Ciencias Funcionales. Barquisimeto, Venezuela.
Universidad Centroccidental Lisandro Alvarado. Escuela de Ciencias Veterinarias. Unidad de Investigación en Ciencias Funcionales. Barquisimeto, Venezuela.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Rio de Janeiro, RJ, Brasil.
Universidad Centroccidental Lisandro Alvarado. Escuela de Ciencias Veterinarias. Unidad de Investigación en Ciencias Funcionales. Barquisimeto, Venezuela.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Rio de Janeiro, RJ, Brasil.
Abstract
Cold acclimatization (4-5°C) is accompanied by 2-3 fold increase of brown adipose tissue (BAT).
This rapid growth of interscapular BAT was studied after histamine depletion. In control rats maintained at room temperature (28 ± 2°C) the BAT histamine content was 23.4 ± 5.9 (mean ± SD) µg/g of
tissue and cold acclimatization (5±1°C) produced a significant increase of BAT weight, but reduced the
histamine content to 8.4 ± 1.9 µg/g. The total weight of BAT after 20 days of acclimatization was unaffected by depletion of histamine due to compound 48/80. The low level of histamine in BAT of cold
acclimatized rats could be due to a fast rate of amine utilization; alternatively an altered synthesis or
storage process may occur during acclimatization.
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