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ZIKA VIRUS INFECTION LEADS TO VARIABLE DEFECTS IN MULTIPLE NEUROLOGICAL FUNCTIONS AND BEHAVIORS IN MICE AND CHILDREN
Abnormal behaviors
Microcephaly
Neurological functions
Visual cortical functions
Author
Affilliation
Chinese Academy of Sciences. Institute of Genetics and Developmental Biology / School of Future Technology. CAS Center for Excellence in Brain Science and Intelligence Technology / State Key Laboratory of Molecular Developmental Biology. Neijing, China.
Beijing Normal University. McGovern Institute for Brain Research / State Key Laboratory of Cognitive Neuroscience & Learning. Beijing, China.
Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil.
Stanford University. Institute for Immunity Transplantation and Infection. Stanford, CA, USA.
Chinese Academy of Sciences. Institute of Genetics and Developmental Biology / School of Future Technology. CAS Center for Excellence in Brain Science and Intelligence Technology / State Key Laboratory of Molecular Developmental Biology. Neijing, China.
Chinese Academy of Medical Sciences & Peking Union Medical College. Institute of Basic Medical Sciences. Center for Systems Medicine. Beijing, China / Suzhou Institute of Systems Medicine. Suzhou, Jiangsu, China.
Beijing Normal University. McGovern Institute for Brain Research / State Key Laboratory of Cognitive Neuroscience & Learning. Beijing, China.
Beijing Normal University. McGovern Institute for Brain Research / State Key Laboratory of Cognitive Neuroscience & Learning. Beijing, China.
Beijing Normal University. McGovern Institute for Brain Research / State Key Laboratory of Cognitive Neuroscience & Learning. Beijing, China.
Zilkha Neurogenetic Institute. University of Southern California. Keck School of Medicine. Department of Obstetrics and Gynecology. Department of Molecular Microbiology and Immunology and Division of Maternal-Fetal Medicine. Los Angeles, CA, USA.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Doenças Febris Agudas. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil.
Beijing Institute of Microbiology and Epidemiology. State Key Laboratory of Pathogen and Biosecurity. Department of Virology. Beijing, China.
UCLA. Mattel Children’s Hospital. David Geffen School of Medicine. Division of Pediatric Infectious Diseases. Los Angeles, CA, USA.
UCLA. Mattel Children’s Hospital. David Geffen School of Medicine. Division of Pediatric Infectious Diseases. Los Angeles, CA, USA.
Chinese Academy of Medical Sciences & Peking Union Medical College. Institute of Basic Medical Sciences. Center for Systems Medicine. Beijing, China / Suzhou Institute of Systems Medicine. Suzhou, Jiangsu, China / University of California. Department of Microbiology Immunology and Molecular Genetics. Los Angeles, CA, USA.
Beijing Normal University. McGovern Institute for Brain Research / State Key Laboratory of Cognitive Neuroscience & Learning. Beijing, China.
Chinese Academy of Sciences. Institute of Genetics and Developmental Biology / School of Future Technology. CAS Center for Excellence in Brain Science and Intelligence Technology / State Key Laboratory of Molecular Developmental Biology / Parkinson's Disease Center Beijing Institute for Brain Disorders. Beijing, China.
Beijing Normal University. McGovern Institute for Brain Research / State Key Laboratory of Cognitive Neuroscience & Learning. Beijing, China.
Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil.
Stanford University. Institute for Immunity Transplantation and Infection. Stanford, CA, USA.
Chinese Academy of Sciences. Institute of Genetics and Developmental Biology / School of Future Technology. CAS Center for Excellence in Brain Science and Intelligence Technology / State Key Laboratory of Molecular Developmental Biology. Neijing, China.
Chinese Academy of Medical Sciences & Peking Union Medical College. Institute of Basic Medical Sciences. Center for Systems Medicine. Beijing, China / Suzhou Institute of Systems Medicine. Suzhou, Jiangsu, China.
Beijing Normal University. McGovern Institute for Brain Research / State Key Laboratory of Cognitive Neuroscience & Learning. Beijing, China.
Beijing Normal University. McGovern Institute for Brain Research / State Key Laboratory of Cognitive Neuroscience & Learning. Beijing, China.
Beijing Normal University. McGovern Institute for Brain Research / State Key Laboratory of Cognitive Neuroscience & Learning. Beijing, China.
Zilkha Neurogenetic Institute. University of Southern California. Keck School of Medicine. Department of Obstetrics and Gynecology. Department of Molecular Microbiology and Immunology and Division of Maternal-Fetal Medicine. Los Angeles, CA, USA.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Doenças Febris Agudas. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil.
Beijing Institute of Microbiology and Epidemiology. State Key Laboratory of Pathogen and Biosecurity. Department of Virology. Beijing, China.
UCLA. Mattel Children’s Hospital. David Geffen School of Medicine. Division of Pediatric Infectious Diseases. Los Angeles, CA, USA.
UCLA. Mattel Children’s Hospital. David Geffen School of Medicine. Division of Pediatric Infectious Diseases. Los Angeles, CA, USA.
Chinese Academy of Medical Sciences & Peking Union Medical College. Institute of Basic Medical Sciences. Center for Systems Medicine. Beijing, China / Suzhou Institute of Systems Medicine. Suzhou, Jiangsu, China / University of California. Department of Microbiology Immunology and Molecular Genetics. Los Angeles, CA, USA.
Beijing Normal University. McGovern Institute for Brain Research / State Key Laboratory of Cognitive Neuroscience & Learning. Beijing, China.
Chinese Academy of Sciences. Institute of Genetics and Developmental Biology / School of Future Technology. CAS Center for Excellence in Brain Science and Intelligence Technology / State Key Laboratory of Molecular Developmental Biology / Parkinson's Disease Center Beijing Institute for Brain Disorders. Beijing, China.
Abstract
Zika virus (ZIKV) has evolved into a global health threat because of its causal link to congenital Zika syndrome. ZIKV infection of pregnant women may cause a spectrum of abnormalities in children. In the studies in Brazil, a large cohort of children with perinatal exposure to ZIKV is followed, and a spectrum of neurodevelopmental abnormalities is identified. In parallel, it is demonstrated that infection of the mouse neonatal brain by a contemporary ZIKV strain instead of an Asian ancestral strain can cause microcephaly and various abnormal neurological functions. These include defects in social interaction and depression, impaired learning and memory, in addition to severe motor defects, which are present in adult mice as well as in the prospective cohort of children. Importantly, although mouse brains infected later after birth do not have apparent abnormal brain structure, those mice still show significant impairments of visual cortical functions, circuit organization, and experience-dependent plasticity. Thus, the study suggests that special attention should be paid to all children born to ZIKV infected mothers for screening of abnormal behaviors and sensory function during childhood.
Keywords
Zika virusAbnormal behaviors
Microcephaly
Neurological functions
Visual cortical functions
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