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Title: Yellow fever transmission in non-human primates, Bahia, Northeastern Brazil
Authors: Jesus, Jaqueline Goes de
Graf, Tiago
Giovanetti, Marta
Mares-Guia, Maria Angélica
Xavier, Joilson
Maia, Maricelia Lima
Fonseca, Vagner
Fabri, Allison
Santos, Roberto Fonseca dos
Pereira, Felicidade Mota
Santos, Leandro Ferraz Oliveira
Silva, Luciana Reboredo de Oliveira da
Maia, Zuinara Pereira Gusmão
Cerqueira, Jananci Xavier Gomes
Thèze, Julien
Abade, Leandro
Cordeiro, Mirza de Carvalho Santana
Torquato, Sintia Sacramento Cerqueira
Santana, Eloisa Bahia
Silva, Neuza Santos de Jesus
Dourado, Rosemary Sarmento Oiticica
Alves, Ademilson Brás
Guedes, Adeilde do Socorro
Silva Filho, Pedro Macedo da
Faria, Nuno Rodrigues
Albuquerque, Carlos F. Campelo de
Abreu, André Luiz de
Romano, Alessandro Pecego Martins
Croda, Julio
Said, Rodrigo Fabiano do Carmo
Cunha, Gabriel Muricy
Cerqueira, Jeane Magnavita da Fonseca
Mello, Arabela Leal e Silva de
Filippis, Ana Maria Bispo de
Alcantara, Luiz Carlos Junior
Affilliation: "Múltipla – ver em notas”
Abstract: Yellow fever virus (YFV) causes a clinical syndrome of acute hemorrhagic hepatitis. YFV transmission involves non-human primates (NHP), mosquitoes and humans. By late 2016, Brazil experienced the largest YFV outbreak of the last 100 years, with 2050 human confirmed cases, with 681 cases ending in death and 764 confirmed epizootic cases in NHP. Among affected areas, Bahia state in Northeastern was the only region with no autochthonous human cases. By using next generation sequence approach, we investigated the molecular epidemiology of YFV in NHP in Bahia and discuss what factors might have prevented human cases. We investigated 47 YFV positive tissue samples from NHP cases to generate 8 novel YFV genomes. ML phylogenetic tree reconstructions and automated subtyping tools placed the newly generated genomes within the South American genotype I (SA I). Our analysis revealed that the YFV genomes from Bahia formed two distinct well-supported phylogenetic clusters that emerged most likely of an introduction from Minas Gerais and Espı´rito Santo states. Vegetation coverage analysis performed shows predominantly low to medium vegetation coverage in Bahia state. Together, our findings support the hypothesis of two independent YFV SA-I introductions. We also highlighted the effectiveness of the actions taken by epidemiological surveillance team of the state to prevented human cases.
Keywords: Yellow Fever
Yellow fever virus
Epidemiologic Surveillance Services
keywords: Febre amarela
Virus da febre amarela
Serviços de Vigilância Epidemiológica
Issue Date: 2020
Publisher: Public Library of Science
Citation: JESUS, Jaqueline Goes de et al. fever transmission in non-human primates, Bahia, Northeastern Brazil. PLoS Neglected Tropical Diseases, aug. 2020.
Description: 1 Laborato´ rio de Patologia Experimental, Instituto Gonc¸alo Moniz, Fundac¸ão Oswaldo Cruz, Salvador, Brazil, 2 Laborato´ rio de Parasitologia Me´ dica, Instituto de Medicina Tropical de São Paulo, Universidade de São Paulo, São Paulo, Brazil, 3 Laboratorio de Flavivirus, Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil, 4 Laborato´ rio de Gene´ tica Celular e Molecular, ICB, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil, 5 Universidade Estadual de Feira de Santana, Feira de Santana, Brazil, 6 Secretaria de Sau´de de Feira de Santana, Ministe´ rio da Sau´de, Feira de Santana, Brazil, 7 KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), College of Health Sciences, University of KwaZulu-Natal, Durban 4001, South Africa, 8 Laborato´ rio Central de Sau´de Pu´ blica da Bahia Professor Gonc¸alo Moniz (LACEN/BA), Salvador, Bahia, Brazil, 9 Faculdade Maria Milza—FAMAM, Bahia, Brazil, 10 Vigilaˆncia Epidemiolo´gica do Estado da Bahia, Secretaria de Sau´de do Estado da Bahia, Salvador, Brazil, 11 Department of Zoology, University of Oxford, Oxford, United Kingdom, 12 The Global Health Network, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, 13 Organizac¸ão Pan- Americana da Sau´de/Organizac¸ão Mundial da Sau´de, Brası´lia, Distrito Federal, Brazil, 14 Coordenac¸ão Geral dos Laborato´ rios de Sau´de Pu´blica/Secretaria de Vigilaˆncia em Sau´de, Ministe´ rio da Sau´de, (CGLAB/ SVS-MS) Brası´lia, Distrito Federal, Brazil, 15 Coordenac¸ão Geral de Vigilaˆncia de Arboviroses (CGARB), 16 Departamento de Vigilaˆncia de Doenc¸as Transmissı´veis/Secretaria de Vigilaˆncia em Sau´de, Ministe´ rio da Sau´de (DEVIT/SVS-MS)
DOI: 10.1371/journal.pntd.0008405
ISSN: 1935-2735
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos
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