| Author | Andrade, Thereza Christina Benévolo de | |
| Author | Maia, Renata Monteiro | |
| Author | Cosgrove, Catherine | |
| Author | Castello Branco, Luiz Roberto R. | |
| Access date | 2020-11-20T14:37:21Z | |
| Available date | 2020-11-20T14:37:21Z | |
| Document date | 2005 | |
| Citation | ANDRADE, Thereza Christina Benévolo de et al. BCG Moreau Rio de Janeiro - An oral vaccine against tuberculosis — review. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 100, n. 5, p. 459-465, Aug. 2005. | pt_BR |
| ISSN | 0074-0276 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/44556 | |
| Language | eng | pt_BR |
| Publisher | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. | pt_BR |
| Rights | open access | |
| Subject in Portuguese | BCG Moreau Rio de Janeiro | pt_BR |
| Subject in Portuguese | Vacina oral | pt_BR |
| Subject in Portuguese | Revisão | pt_BR |
| Title | BCG Moreau Rio de Janeiro - An oral vaccine against tuberculosis – Review | pt_BR |
| Type | Article | |
| DOI | 10.1590/S0074-02762005000500002 | |
| Abstract | The vaccine Bacillus of Calmette Guérin (BCG) was originally developed in France as an oral vaccine against
tuberculosis. The oral use of this vaccine was replaced by the parenteral route in almost all countries after the
Lubeck disaster. In contrast, Brazil retained the oral delivery of the vaccine until the mid-seventies when it was
replaced by the intradermal route. This change in route of delivery was mainly secondary to pressure by medical
practitioners based on the poor responses of oral immunized subjects to purified protein derivative (PPD) skin tests.
Even after the change of route of delivery, Ataulpho de Paiva Foundation continued making the oral vaccine.
Currently, BCG Moreau has been described as one of the most immunogenic and with fewer side effects than other
BCGs. The genomics, proteomics and vaccine trials for oral BCG Moreau Rio de Janeiro are currently under
investigation. In this review, we intend to describe the history of BCG Moreau Rio de Janeiro in Brazil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Imunologia Clínica. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Ataulpho de Paiva. Centro de Pesquisas Arlindo de Assis. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | St. George's Hospital Medical School. Division of Infectious Diseases. London, UK. | pt_BR |
| Affilliation | Fundação Ataulpho de Paiva. Centro de Pesquisas Arlindo de Assis. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | BCG Moreau Rio de Janeiro | pt_BR |
| Subject | Oral vaccine | pt_BR |
| Subject | Review | pt_BR |
| e-ISSN | 1678-8060 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
