Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/44556
Title: BCG Moreau Rio de Janeiro - An oral vaccine against tuberculosis – Review
Authors: Andrade, Thereza Christina Benévolo de
Maia, Renata Monteiro
Cosgrove, Catherine
Castello Branco, Luiz Roberto R.
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Imunologia Clínica. Rio de Janeiro, RJ, Brasil.
Fundação Ataulpho de Paiva. Centro de Pesquisas Arlindo de Assis. Rio de Janeiro, RJ, Brasil.
St. George's Hospital Medical School. Division of Infectious Diseases. London, UK.
Fundação Ataulpho de Paiva. Centro de Pesquisas Arlindo de Assis. Rio de Janeiro, RJ, Brasil.
Abstract: The vaccine Bacillus of Calmette Guérin (BCG) was originally developed in France as an oral vaccine against tuberculosis. The oral use of this vaccine was replaced by the parenteral route in almost all countries after the Lubeck disaster. In contrast, Brazil retained the oral delivery of the vaccine until the mid-seventies when it was replaced by the intradermal route. This change in route of delivery was mainly secondary to pressure by medical practitioners based on the poor responses of oral immunized subjects to purified protein derivative (PPD) skin tests. Even after the change of route of delivery, Ataulpho de Paiva Foundation continued making the oral vaccine. Currently, BCG Moreau has been described as one of the most immunogenic and with fewer side effects than other BCGs. The genomics, proteomics and vaccine trials for oral BCG Moreau Rio de Janeiro are currently under investigation. In this review, we intend to describe the history of BCG Moreau Rio de Janeiro in Brazil.
Keywords: BCG Moreau Rio de Janeiro
Oral vaccine
Review
keywords: BCG Moreau Rio de Janeiro
Vacina oral
Revisão
Issue Date: 2005
Publisher: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
Citation: ANDRADE, Thereza Christina Benévolo de et al. BCG Moreau Rio de Janeiro - An oral vaccine against tuberculosis — review. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 100, n. 5, p. 459-465, Aug. 2005.
DOI: 10.1590/S0074-02762005000500002
ISSN: 0074-0276
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos
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