The Memórias do Instituto Oswaldo Cruz, officially created by Oswaldo Cruz in 1907 to divulge researches developed at the Institute, had its first volume publicated in 1909 (Tome I). During this 96 years of existence, the journal developed with several inovations until the publication of volume 100, in 2005, maintaining its scientific excelence and tradition. From volume 75, published in 1980, the Memórias launched a progressive process of modernization turning into an international journal, publishing papers from Brazilian and foreign scientists from all over the World. Consequently, from 1987 on, the Memórias started publishing its articles preferentially in English for a better disclosure. Indexed by the Science Citation Index and other international indexes it is considered by Bioline one of the most consulted international journal in the biomedical field in Latin America and the fourth most cited in the field of Tropical Medicine in the whole World.