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FIRST ENCOUNTER OF SUBCLINICAL HUMAN LEISHMANIA (VIANNIA) INFECTION IN STATE OF RIO GRANDE DO SUL, BRAZIL
Reação em cadeia de polimerase
Teste de pele de Montenegro
Rio Grande do Sul
Subclinical infection
Brasil
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Abstract
The objective of the present study was to evaluate the specificity of the Montenegro skin test (MST) in an area in Brazil, state of Grande do Sul State (RS), which was considered to be non-endemic for leishmaniasis. Sixty subjects presented a positive MST and were reevaluated by clinical examination, serology and polymerase chain reaction (PCR) of peripheral blood for the detection of subclinical Leishmania infection. None of the subjects presented clinical signs or symptoms of current leishmaniasis or a history of the disease. Leishmania (Viannia) DNA was detected in blood by PCR and hybridization in one subject. The PCR skin test-positive individual remained asymptomatic throughout the study. Clinical examination showed no scars suggestive of past cutaneous leishmaniasis. Human subclinical infection with Leishmania (Viannia) in RS was confirmed by PCR. This is the first report of subclinical infection with this parasite in the human population of this area.
Keywords in Portuguese
LeishmaniaReação em cadeia de polimerase
Teste de pele de Montenegro
Rio Grande do Sul
Subclinical infection
Brasil
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