| Author | Santos, Camila C. | |
| Author | Zhang, Huaisheng | |
| Author | Batista, Marcos M. | |
| Author | Oliveira, Gabriel M. de | |
| Author | Demarque, kelly C. | |
| Author | Gomes, Natália L. da Silva | |
| Author | Moreira, Otacilio C. | |
| Author | Ogungbe, Ifedayo Victor | |
| Author | Soeiro, Maria de Nazaré C. | |
| Access date | 2020-11-30T18:32:33Z | |
| Available date | 2020-11-30T18:32:33Z | |
| Document date | 2020 | |
| Citation | SANTOS, Camila C. et al. In Vitro and In Vivo Evaluation of an Adamantyl-Based Phenyl Sulfonyl Acetamide against Cutaneous Leishmaniasis Models of Leishmania amazonensis. Antimicrobial Agents and Chemotherapy, v. 64, n. 12, e01188-20, 6p, Dec. 2020. | pt_BR |
| ISSN | 0066-4804 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/44684 | |
| Language | eng | pt_BR |
| Publisher | American Society for Microbiology | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Quimioterapia experimental | pt_BR |
| Subject in Portuguese | Leishmaniose Cutânea | pt_BR |
| Subject in Portuguese | Adamantyl | pt_BR |
| Title | In Vitro and In Vivo Evaluation of an Adamantyl-Based Phenyl Sulfonyl Acetamide against Cutaneous Leishmaniasis Models of Leishmania amazonensis | pt_BR |
| Type | Article | |
| DOI | 10.1128/AAC.01188-20 | |
| Abstract | Phenotypic assay against Leishmania amazonensis in vitro and in vivo
led to identification of an adamantyl-based phenyl sulfonyl acetamide (compound 1)
as a promising antileishmanial agent. Compound 1 inhibited the growth of intracellular
forms of L. amazonensis (50% inhibitory concentration [IC50] 4 M) and exhibited
low toxicity to host cells, with a selectivity index (SI) of 125. However, in a
cutaneous leishmaniasis (CL) mouse model, compound 1 did not reduce lesions and
parasite load when administered as monotherapy or when given simultaneously
with a suboptimal dose of miltefosine. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Jackson State University. Department of Chemistry, Physics and Atmospheric Science. Jackson, Mississippi, USA. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia. Molecular e Doenças Endêmicas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia. Molecular e Doenças Endêmicas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Jackson State University. Department of Chemistry, Physics and Atmospheric Science. Jackson, Mississippi, USA. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Cutaneous leishmaniasis | pt_BR |
| Subject | Adamantyl | pt_BR |
| Subject | Phenyl sulfonyl acetamide | pt_BR |
| Subject | Experimental chemotherapy | pt_BR |
