Sporotrichosis is a subcutaneous mycosis caused by thermodimorphic fungi of Sporothrix schenckii complex and is usually transmitted as a result of traumatic inoculation of these microorganisms; infection can produce a number of manifestations. 1,2 In Brazil, sporotrichosis has been a major public health issue, with multiple outbreaks occurring because of zoonotic transmission, including contact with cats, and S brasiliensis is the most prevalent agent in Rio de Janeiro State.3,4 Immunocompromised individuals are thought to be at increased risk of developing a more severe clinical presentation.5 Disseminated sporotrichosis in immunocompetent individuals as result of contact with cats has becoming increasingly reported. 6,7 Historically, cases of sporotrichosis in the Brazilian northeast have been infrequently reported, and this was not thought to be an endemic area for this mycosis. Herein, we report 4 cases of disseminated sporotrichosis in patients in a public hospital in Pernambuco. Publication of this case series report was granted institutional review board approval by the Ethics Committee in Research at the Federal University of Pernambuco, Brazil.