Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/4590
Title: Oral transmission of Chagas disease: importance of Trypanosoma cruzi biodeme in the intragastric experimental infection.
Authors: Camandaroba, Edson Luiz Paes
Lima, Clarissa M. Pinheiro
Andrade, Sonia Gumes
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Abstract: Oral transmission of Trypanosoma cruzi has been suspected when epidemic episodes of acute infection were observed in areas devoid of domiciled insect vectors. Considering that the distribution of T. cruzi biodemes differs in sylvatic and domestic cycles, results of studies on biodemes can be of interest regarding oral transmission. The infectivity of T. cruzi strains of different biodemes was tested in mice subjected to infection by the digestive route (gavage). Swiss mice were infected either with the Peruvian strain (Biodeme Type I, Z2b) or the Colombian strain (Biodeme Type III, Z1, or T. cruzi I); for control, intraperitoneal inoculation was performed in a group of mice. The Colombian strain revealed a similar high infectivity and pathogenicity when either route of infection was used. However, the Peruvian strain showed contrasting levels of infectivity and pathogenicity, being high by intraperitoneal inoculation and low when the gastric route was used. The higher infectivity of the Colombian strain (Biodeme Type III) by gastric inoculation is in keeping with its role in the epidemic episodes of acute Chagas disease registered in the literature, since strains belonging to Biodeme III are most often found in sylvatic hosts.
keywords: Trypanosoma cruzi
Oral transmission
Experimental intragastric infection; T.cruzi strains infectivity
Biodemes.
DeCS: Doença de Chagas/transmissão
Trypanosoma cruzi/patogenicidade
Animais
Doença de Chagas/parasitologia
Doença de Chagas/patologia
Modelos Animais de Doenças
Camundongos
Fatores de Tempo
Issue Date: 2002
Citation: CAMANDAROBA, E.L.; LIMA, C.M.P.; ANDRADE, S.G.Oral transmission of Chagas disease: importance of Trypanosoma cruzi biodeme in the intragastric experimental infection. Revista do Instituto de Medicina Tropical de Sao Paulo, v. 44, n. 2, p. 97-103, mar.-apr. 2002.
ISSN: 0036-4665
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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