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BIOLOGICAL AND PHYSICAL APPROACHES ON THE ROLE OF PIPLARTINE (PIPERLONGUMINE) IN CANCER
Autor
Afiliación
School of Medicine of São José do Rio Preto. Department of Molecular Biology. São José do Rio Preto, SP, Brazil.
São Paulo State University. Institute of Biosciences, Humanities and Exact Sciences. Department of Biology. São José do Rio Preto, SP, Brazil.
São Paulo State University. Institute of Biosciences, Humanities and Exact Sciences. Department of Biology. São José do Rio Preto, SP, Brazil / Integrated College Padre Albino Foundation. Catanduva, SP, Brazil.
School of Medicine of São José do Rio Preto. Department of Molecular Biology. São José do Rio Preto, SP, Brazil / University of São Paulo. Institute of Biosciences. Department of Genetics and Evolutive Biology. São Paulo, SP, Brazil.
São Paulo State University. Institute of Biosciences, Humanities and Exact Sciences. Department of Physics. São José do Rio Preto, SP, Brazil.
Federal University of Alfenas. Institute of Chemistry. Laboratory of Molecular Modeling and Computer Simulation/MolMod. Alfenas, MG, Brazil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil.
Federal University of Ceará. Department of Chemistry. Fortaleza, CE, Brazil.
Federal University of Paraiba. Laboratory of Pharmaceutics Technology. João Pessoa, PB, Brazil.
Federal University of Alfenas. Institute of Chemistry. Laboratory of Molecular Modeling and Computer Simulation/MolMod. Alfenas, MG, Brazil.
São Paulo State University. Institute of Biosciences, Humanities and Exact Sciences. Department of Biology. São José do Rio Preto, SP, Brazil.
School of Medicine of São José do Rio Preto. Department of Molecular Biology. São José do Rio Preto, SP, Brazil./ University of São Paulo. Institute of Biosciences. Department of Genetics and Evolutive Biology. São Paulo, SP, Brazil.
São Paulo State University. Institute of Biosciences, Humanities and Exact Sciences. Department of Biology. São José do Rio Preto, SP, Brazil.
São Paulo State University. Institute of Biosciences, Humanities and Exact Sciences. Department of Biology. São José do Rio Preto, SP, Brazil / Integrated College Padre Albino Foundation. Catanduva, SP, Brazil.
School of Medicine of São José do Rio Preto. Department of Molecular Biology. São José do Rio Preto, SP, Brazil / University of São Paulo. Institute of Biosciences. Department of Genetics and Evolutive Biology. São Paulo, SP, Brazil.
São Paulo State University. Institute of Biosciences, Humanities and Exact Sciences. Department of Physics. São José do Rio Preto, SP, Brazil.
Federal University of Alfenas. Institute of Chemistry. Laboratory of Molecular Modeling and Computer Simulation/MolMod. Alfenas, MG, Brazil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil.
Federal University of Ceará. Department of Chemistry. Fortaleza, CE, Brazil.
Federal University of Paraiba. Laboratory of Pharmaceutics Technology. João Pessoa, PB, Brazil.
Federal University of Alfenas. Institute of Chemistry. Laboratory of Molecular Modeling and Computer Simulation/MolMod. Alfenas, MG, Brazil.
São Paulo State University. Institute of Biosciences, Humanities and Exact Sciences. Department of Biology. São José do Rio Preto, SP, Brazil.
School of Medicine of São José do Rio Preto. Department of Molecular Biology. São José do Rio Preto, SP, Brazil./ University of São Paulo. Institute of Biosciences. Department of Genetics and Evolutive Biology. São Paulo, SP, Brazil.
Resumen en ingles
Chronic inflammation provides a favorable microenvironment for tumorigenesis, which opens
opportunities for targeting cancer development and progression. Piplartine (PL) is a biologically
active alkaloid from long peppers that exhibits anti-inflammatory and antitumor activity. In the
present study, we investigated the physical and chemical interactions of PL with anti-inflammatory
compounds and their effects on cell proliferation and migration and on the gene expression of
inflammatory mediators. Molecular docking data and physicochemical analysis suggested that PL
shows potential interactions with a peptide of annexin A1 (ANXA1), an endogenous anti-inflammatory
mediator with therapeutic potential in cancer. Treatment of neoplastic cells with PL alone or with
annexin A1 mimic peptide reduced cell proliferation and viability and modulated the expression of
MCP-1 chemokine, IL-8 cytokine and genes involved in inflammatory processes. The results also
suggested an inhibitory effect of PL on tubulin expression. In addition, PL apparently had no influence
on cell migration and invasion at the concentration tested. Considering the role of inflammation in
the context of promoting tumor initiation, the present study shows the potential of piplartine as a
therapeutic immunomodulator for cancer prevention and progression.
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