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COLONIZATION AND GENETIC DIVERSIFICATION PROCESSES OF LEISHMANIA INFANTUM IN THE AMERICAS
Author
Schwabl, Philipp
Boité, Mariana C.
Bussotti, Giovanni
Jacobs, Arne
Andersson, Bjorn
Moreira, Otacílio
Mesquita, Anita L. Freitas
Fernandes, Jose Roberto Meyer
Telleria, Erich L.
Traub-Csekö, Yara
Vaselek, Slavica
Leštinová, Tereza Leštinová
Volf, Petr
Morgado, Fernanda N.
Porrozzi, Renato
Llewellyn, Martin
Späth, Gerald F.
Cupolillo, Elisa
Boité, Mariana C.
Bussotti, Giovanni
Jacobs, Arne
Andersson, Bjorn
Moreira, Otacílio
Mesquita, Anita L. Freitas
Fernandes, Jose Roberto Meyer
Telleria, Erich L.
Traub-Csekö, Yara
Vaselek, Slavica
Leštinová, Tereza Leštinová
Volf, Petr
Morgado, Fernanda N.
Porrozzi, Renato
Llewellyn, Martin
Späth, Gerald F.
Cupolillo, Elisa
Affilliation
School of Life Sciences, Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow, G12 8QQ Glasgow, UK.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmaniose. Rio de Janeiro, RJ, Brasil.
Institut Pasteur-Bioinformatics and Biostatistics Hub-C3BI, USR 3756 IP CNRS, 75015 Paris, France / Department of Parasites and Insect Vectors, Institut Pasteur, INSERM U1201, Unité de Parasitology moléculaire et Signalisation, 75015 Paris, France.
School of Life Sciences, Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow, G12 8QQ Glasgow, UK.
Department of Cell and Molecular Biology, Science for Life Laboratory, Karolinska Institutet, Biomedicum 9C, 171 77 Stockholm, Sweden
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Biologia Molecular e Doenças Endêmicas. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Parasitas e Vetores. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Parasitas e Vetores,. Rio de Janeiro, RJ Brasil ./ Faculty of Science, Department of Parasitology, Charles University, 128 44 Prague, Czech Republic..
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Parasitas e Vetores,. Rio de Janeiro, RJ Brasil.
Faculty of Science, Department of Parasitology, Charles University, 128 44 Prague, Czech Republic.
Faculty of Science, Department of Parasitology, Charles University, 128 44 Prague, Czech Republic.
Faculty of Science, Department of Parasitology, Charles University, 128 44 Prague, Czech Republic.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmaniose. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmaniose. Rio de Janeiro, RJ, Brasil.
School of Life Sciences, Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow, G12 8QQ Glasgow, UK.
School of Life Sciences, Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow, G12 8QQ Glasgow, UK.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmaniose. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmaniose. Rio de Janeiro, RJ, Brasil.
Institut Pasteur-Bioinformatics and Biostatistics Hub-C3BI, USR 3756 IP CNRS, 75015 Paris, France / Department of Parasites and Insect Vectors, Institut Pasteur, INSERM U1201, Unité de Parasitology moléculaire et Signalisation, 75015 Paris, France.
School of Life Sciences, Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow, G12 8QQ Glasgow, UK.
Department of Cell and Molecular Biology, Science for Life Laboratory, Karolinska Institutet, Biomedicum 9C, 171 77 Stockholm, Sweden
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Biologia Molecular e Doenças Endêmicas. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Parasitas e Vetores. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Parasitas e Vetores,. Rio de Janeiro, RJ Brasil ./ Faculty of Science, Department of Parasitology, Charles University, 128 44 Prague, Czech Republic..
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Parasitas e Vetores,. Rio de Janeiro, RJ Brasil.
Faculty of Science, Department of Parasitology, Charles University, 128 44 Prague, Czech Republic.
Faculty of Science, Department of Parasitology, Charles University, 128 44 Prague, Czech Republic.
Faculty of Science, Department of Parasitology, Charles University, 128 44 Prague, Czech Republic.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmaniose. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmaniose. Rio de Janeiro, RJ, Brasil.
School of Life Sciences, Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow, G12 8QQ Glasgow, UK.
School of Life Sciences, Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow, G12 8QQ Glasgow, UK.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmaniose. Rio de Janeiro, RJ, Brasil.
Abstract
Leishmania infantum causes visceral leishmaniasis, a deadly vector-borne disease introduced to the Americas during the colonial era. This non-native trypanosomatid parasite has since established widespread transmission cycles using alternative vectors, and human infection has become a significant concern to public health, especially in Brazil. A multi-kilobase deletion was recently detected in Brazilian L. infantum genomes and is suggested to reduce susceptibility to the anti-leishmanial drug miltefosine. We show that deletion-carrying strains occur in at least 15 Brazilian states and describe diversity patterns suggesting that these derive from common ancestral mutants rather than from recurrent independent mutation events. We also show that the deleted locus and associated enzymatic activity is restored by hybridization with non-deletion type strains. Genetic exchange appears common in areas of secondary contact but also among closely related parasites. We examine demographic and ecological scenarios underlying this complex L. infantum population structure and discuss implications for disease control.
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