| Author | Teixeira, Guilherme Pegas | |
| Author | Faria, Robson Xavier | |
| Access date | 2021-02-19T20:28:40Z | |
| Available date | 2021-02-19T20:28:40Z | |
| Document date | 2021 | |
| Citation | TEIXEIRA, Guilherme Pegas; FARIA, Robson Xavier. Influence of purinergic signaling on glucose transporters: A possible mechanism against insulin resistance? European Journal of Pharmacology, v. 892, p. 1-10, 2021. | pt_BR |
| ISSN | 0014-2999 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/46117 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Transportadores de glicose | pt_BR |
| Subject in Portuguese | Diabetes tipo 2 | pt_BR |
| Subject in Portuguese | Sinalização purinérgica | pt_BR |
| Subject in Portuguese | Insulin resistance | pt_BR |
| Subject in Portuguese | Inflamação | pt_BR |
| Title | Influence of purinergic signaling on glucose transporters: A possible mechanism against insulin resistance? | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.ejphar.2020.173743 | |
| Abstract | Metabolic disorders, such as insulin resistance, affect many people worldwide due to the prevalence of obesity
and type 2 diabetes, which are pathologies that impair glycemic metabolism. Glucose is the primary energetic
substrate of the body and is essential for cellular function. As the cell membrane is not permeable to glucose
molecules, there are two distinct groups of glucose transporters: sodium-glucose-linked transporters (SGLTs) and
the glucose transporter (GLUT) family. These transporters facilitate the entry of glucose into the bloodstream or
cytoplasm where it functions in the production of adenosine 5 ́-triphosphate (ATP). This nucleotide acts in
several cellular mechanisms, such as protein phosphorylation and cellular immune processes. ATP directly and
indirectly acts as an agonist for purinergic receptors in high concentrations in the extracellular environment.
Composed by P1 and P2 groups, the purinoreceptors cover several cellular mechanisms involving cytokines,
tumors, and metabolic signaling pathways. Previous publications have indicated that the purinergic signaling
activity in insulin resistance and glucose transporters modulates relevant actions on the deregulations that can
affect glycemic homeostasis. Thus, this review focuses on the pharmacological influence of purinergic signaling
on the modulation of glucose transporters, aiming for a new way to combat insulin resistance and other metabolic
disorders. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Toxoplasmose e Outras Protozoases. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Toxoplasmose e Outras Protozoases. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Glucose transporters | pt_BR |
| Subject | Purinergic signaling | pt_BR |
| Subject | Insulin resistance | pt_BR |
| Subject | Inflammation | pt_BR |
| Embargo date | 2023 | |
