Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/46125
Title: Genetic polymorphisms in vitamin D pathway influence 25(OH)D levels and are associated with atopy and asthma
Authors: Galvão, Alana Alcântara
Sena, Flávia de Araújo
Belitardo, Emília Maria Medeiros de Andrade
Santana, Maria Borges Rabelo de
Costa, Gustavo Nunes de Oliveira
Cruz, Álvaro Augusto
Barreto, Maurício Lima
Costa, Ryan dos Santos
Neves, Neuza Maria Alcantara
Figueiredo, Camila Alexandrina
Affilliation: Universidade Federal da Bahia. Instituto de Ciências da Bahia. Salvador, BA, Brasil / Programa de Pós Graduação em Imunologia. Salvador, BA, Brasil.
Universidade Federal da Bahia. Instituto de Ciências da Bahia. Salvador, BA, Brasil / Programa de Pós Graduação em Imunologia. Salvador, BA, Brasil.
Universidade Federal da Bahia. Instituto de Ciências da Bahia. Salvador, BA, Brasil / Programa de Pós Graduação em Imunologia. Salvador, BA, Brasil.
Universidade Federal da Bahia. Instituto de Ciências da Bahia. Salvador, BA, Brasil / Programa de Pós Graduação em Imunologia. Salvador, BA, Brasil.
Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil / Universidade Salvador. Salvador, BA, Brasil.
Universidade Federal da Bahia. Faculdade de Medicina. ProAR. Salvador, BA, Brasil.
Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de dados e Conhecimentos para Saúde. Salvador, BA, Brasil.
Universidade Federal da Bahia. Instituto de Ciências da Bahia. Salvador, BA, Brasil / Programa de Pós Graduação em Imunologia. Salvador, BA, Brasil.
Universidade Federal da Bahia. Instituto de Ciências da Bahia. Salvador, BA, Brasil / Programa de Pós Graduação em Imunologia. Salvador, BA, Brasil.
Universidade Federal da Bahia. Instituto de Ciências da Bahia. Salvador, BA, Brasil / Programa de Pós Graduação em Imunologia. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Ciências da Saúde. Departamento de Ciências da Biorregulação. Salvador, BA, Brasil.
Abstract: Vitamin D deficiency or insufficiency, has been associated with atopy and lack of asthma control. Our objective was to investigate associations between variants in genes of vitamin D pathway with serum levels of 25-hydroxyvitamin D (25(OH)D), atopy, asthma and asthma severity in teenagers from Northeast Brazil. Methods: This is a cross sectional study nested in a cohort population of asthma. 25(OH)D was quantified from 968 of 11–17 years old individuals by ELISA. Asthma diagnosis was obtained by using the ISAAC Phase III questionnaire. Specific IgE was determined by ImmunoCAP; genotyping was performed using the 2.5 HumanOmni Biochip from Illumina. Statistical analyses were performed in PLINK 1.07 and SPSS 22.1. Results: After quality control, 104 Single Nucleotides Variants (SNVs) in vitamin D pathway genes, typed in 792 individuals, were included in the analysis. The allele A of rs10875694 on VDR was positively associated with atopy (OR = 1.35; 95% CI 1.01–1.81). The allele C of rs9279 on VDR, was negatively associated with asthma risk (OR = 0.66; 95% CI 0.45–0.97), vitamin D insufficiency (OR = 0.78; 95% CI 0.70–0.96) and higher VDR expression. Two variants in VDR were associated with asthma severity, the allele A of rs2189480 (OR = 0.34; 95% CI 0.13–0.89) and the allele G of rs4328262 (OR = 3.18; 95% CI 1.09–9.28). The combination of variants in CYP2R1 and CYP24A1 (GAC, to rs10500804, rs12794714 and rs3886163, respectively) was negatively associated with vitamin D production (β = − 1.24; 95% CI − 2.42 to − 0.06). Conclusions: Genetic variants in the vitamin D pathway affect vitamin D serum levels and, thus, atopy and asthma
Keywords: Vitamin D
CYP2R1
VDR
CYP24A1
IgE
25(OH)D
SNVs
Asthma
Atopy
keywords: Vitamina D
Imunoglobulina E
Vitamina D3 24-Hidroxilase
Genes
Deficiência de Vitamina D
Asma
Issue Date: 2020
Publisher: BMC
Citation: GALVÃO, Alana Alcântara et al. Genetic polymorphisms in vitamin D pathway influence 25(OH)D levels and are associated with atopy and asthma. Allergy, Asthma & Clinical Immunology, v. 16, 2020.
DOI: 10.1186/s13223-020-00460-y
ISSN: 1710-1484
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos
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