| Author | Santos, Letícia Adrielle dos | |
| Author | Góis Filho, Pedro Germano de | |
| Author | Silva, Ana Maria Fantini | |
| Author | Santos, João Victor Gomes | |
| Author | Santos, Douglas Siqueira | |
| Author | Aquino, Marília Marques | |
| Author | Jesus, Rafaela Mota de | |
| Author | Almeida, Maria Luiza Dória | |
| Author | Silva, João Santana da | |
| Author | Altmann, Daniel M. | |
| Author | Boyton, Rosemary J. | |
| Author | Santos, Cliomar Alves dos | |
| Author | Santos, Camilla Natália Oliveira | |
| Author | Alves, Juliana Cardoso | |
| Author | Santos, Ianaline Lima | |
| Author | Magalhães, Lucas Sousa | |
| Author | Belitardo, Emilia M. M. A. | |
| Author | Rocha, Danilo J. P. G. | |
| Author | Almeida, João P. P. | |
| Author | Pacheco, Luis G. C. | |
| Author | Aguiar, Eric R. G. R. | |
| Author | Campos, Gubio Soares | |
| Author | Sardi, Silvia Inês | |
| Author | Carvalho, Rejane Hughes | |
| Author | Jesus, Amélia Ribeiro de | |
| Author | Rezende, Karla Freire | |
| Author | Almeida, Roque Pacheco de | |
| Access date | 2021-03-05T01:49:04Z | |
| Available date | 2021-03-05T01:49:04Z | |
| Document date | 2021 | |
| Citation | SANTOS, Letícia Adrielle dos et al. Recurrent COVID-19 including evidence of reinfection and enhanced severity in thirty Brazilian healthcare workers. Journal of Infection, p. 1-8, Feb. 2021. | pt_BR |
| ISSN | 0163-4453 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/46266 | |
| Description | Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. | pt_BR |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | open access | pt_BR |
| Title | Recurrent COVID-19 including evidence of reinfection and enhanced severity in thirty Brazilian healthcare workers | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1016/j.jinf.2021.01.020 | |
| Abstract | Background: There is growing concern about individuals reported to suffer repeat COVID-19 disease episodes, these in a small number of cases characterised as de novo infections with distinct sequences, indicative of insufficient protective immunity even in the short term. Methods: Observational case series and case-control studies reporting 33 cases of recurrent, symptomatic, qRTPCR positive COVID-19. Recurrent disease was defined as symptomatic recurrence after symptom-free clinical recovery, with release from isolation >14 days from the beginning of symptoms confirmed by qRT-PCR. The case control study-design compared this group of patients with a control group of 62 patients randomly selected from the same COVID-19 database. Results: Of 33 recurrent COVID-19 patients, 26 were female and 30 were HCW. Mean time to recurrence was 50.5 days which was associated with being a HCW (OR 36.4 (p <0.0001)), and blood type A (OR 4.8 (p = 0.002)).
SARS-CoV-2 antibodies were signifcantly lower in recurrent patients after initial COVID-19 (2.4 ±0.610; p<0.0001) and after recurrence (6.4 ±11.34; p = 0.007). Virus genome sequencing identified reinfection by a different isolate in one patient. Conclusions: This is the first detailed case series showing COVID-19 recurrence with qRT-PCR positivity. For one individual detection of phylogenetically distinct genomic sequences in the first and second episodes confirmed bona fide renfection, but in most cases the data do not formally distinguish between reinfection and re-emergence of a chronic infection reservoir. These episodes were significantly associated with reduced Ab response during initial disease and argue the need for ongoing vigilance without an assumption of protection after a first episode. | pt_BR |
| Affilliation | Federal University of Sergipe. Immunology Investigative Institute (III). Department of Medicine. INCT, CNPq. Aracaju, SE, Brazil. | pt_BR |
| Affilliation | Federal University of Sergipe. Immunology Investigative Institute (III). Department of Medicine. INCT, CNPq. Aracaju, SE, Brazil. | pt_BR |
| Affilliation | Federal University of Sergipe. Immunology Investigative Institute (III). Department of Medicine. INCT, CNPq. Aracaju, SE, Brazil. | pt_BR |
| Affilliation | Federal University of Sergipe. Immunology Investigative Institute (III). Department of Medicine. INCT, CNPq. Aracaju, SE, Brazil. | pt_BR |
| Affilliation | Federal University of Sergipe. Immunology Investigative Institute (III). Department of Medicine. INCT, CNPq. Aracaju, SE, Brazil. | pt_BR |
| Affilliation | Federal University of Sergipe. Immunology Investigative Institute (III). Department of Medicine. INCT, CNPq. Aracaju, SE, Brazil. | pt_BR |
| Affilliation | Institute of Health Promotion and Assistance for Employees of the State of Sergipe. Division of Pulmonology. Aracaju, SE, Brazil. | pt_BR |
| Affilliation | Federal University of Sergipe. Immunology Investigative Institute (III). Department of Medicine. INCT, CNPq. Aracaju, SE, Brazil. | pt_BR |
| Affilliation | Oswaldo Cruz Foundation. Bi-Institutional Translational Medicine Project. Ribeirão Preto Medical School. Department of Biochemistry and Immunology. Ribeirão Preto, SP, Brazil. | pt_BR |
| Affilliation | Hammersmith Hospital. Imperial College. Faculty of Medicine. Department of Immunology and Inflammation. London, United Kingdom. | pt_BR |
| Affilliation | Hammersmith Hospital. Imperial College. Faculty of Medicine. Department of Immunology and Inflammation. London, United Kingdom. | pt_BR |
| Affilliation | State Secretary for Health. Central Laboratory of Public Health. Health Foundation Parreiras Horta. Aracaju, SE, Brazil. | pt_BR |
| Affilliation | Federal University of Sergipe. University Hospital/EBSERH. Division of Immunology and Molecular Biology Laboratory. Aracaju, SE, Brazil. | pt_BR |
| Affilliation | Federal University of Sergipe. University Hospital/EBSERH. Division of Immunology and Molecular Biology Laboratory. Aracaju, SE, Brazil | pt_BR |
| Affilliation | Federal University of Sergipe. University Hospital/EBSERH. Division of Immunology and Molecular Biology Laboratory. Aracaju, SE, Brazil | pt_BR |
| Affilliation | Federal University of Sergipe. University Hospital/EBSERH. Division of Immunology and Molecular Biology Laboratory. Aracaju, SE, Brazil | pt_BR |
| Affilliation | Federal University of Bahia. Institute of Health Sciences. Salvador, BA, Brazil. | pt_BR |
| Affilliation | Federal University of Bahia. Institute of Health Sciences. Salvador, BA, Brazil. | pt_BR |
| Affilliation | Federal University of Minas Gerais. Institute of Biological Sciences. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | Federal University of Bahia. Institute of Health Sciences. Salvador, BA, Brazil. | pt_BR |
| Affilliation | State University of Santa Cruz. Center of Biotechnology and Genetics. Department of Biological Sciences. Ilhéus, bA, Brazil. | pt_BR |
| Affilliation | Federal University of Bahia. Virology Laboratory, Institute of Health Sciences. Salvador, BA, Brazil. | pt_BR |
| Affilliation | Federal University of Bahia. Institute of Health Sciences. Virology Laboratory. Salvador, BA, Brazil. | pt_BR |
| Affilliation | Federal University of Bahia. Institute of Health Sciences. Virology Laboratory. Salvador, BA, Brazil. | pt_BR |
| Affilliation | Federal University of Sergipe. Immunology Investigative Institute (III). Department of Medicine. INCT, CNPq. Aracaju, SE, Brazil / Federal University of Sergipe. University Hospital/EBSERH. Division of Immunology and Molecular Biology Laboratory. Aracaju, SE, Brazil. | pt_BR |
| Affilliation | Federal University of Sergipe. Immunology Investigative Institute (III). Department of Medicine. INCT, CNPq. Aracaju, SE, Brazil. | pt_BR |
| Affilliation | Federal University of Sergipe. Immunology Investigative Institute (III). Department of Medicine. INCT, CNPq. Aracaju, SE, Brazil / Federal University of Sergipe. University Hospital/EBSERH. Division of Immunology and Molecular Biology Laboratory. Aracaju, SE, Brazil. | pt_BR |
| Subject | COVID-19 | pt_BR |
| Subject | Recurrence | pt_BR |
| Subject | Reinfection | pt_BR |
| Subject | SARS-CoV-2 | pt_BR |
| Subject | Antibodies | pt_BR |
