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SARS-COV-2 ENGAGES INFLAMMASOME AND PYROPTOSIS IN HUMAN PRIMARY MONOCYTES
Você pode encontrar a referida correção do artigo neste link: https://www.nature.com/articles/s41420-021-00477-1
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Abstract
Infection by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been associated with leukopenia and uncontrolled inflammatory response in critically ill patients. A better comprehension of SARS-CoV-2-induced monocyte death is essential for the identification of therapies capable to control the hyper-inflammation and reduce viral replication in patients with 2019 coronavirus disease (COVID-19). Here, we show that SARS-CoV-2 engages inflammasome and triggers pyroptosis in human monocytes, experimentally infected, and from patients under intensive care. Pyroptosis associated with caspase-1 activation, IL-1ß production, gasdermin D cleavage, and enhanced pro-inflammatory cytokine levels in human primary monocytes. At least in part, our results originally describe mechanisms by which monocytes, a central cellular component recruited from peripheral blood to respiratory tract, succumb to control severe COVID-19.
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Springer Nature
Citation
FERREIRA, André C. et al. SARS-CoV-2 engages inflammasome and pyroptosis in human primary monocytes. Cell Death Discovery, v. 7, n. 43, p. 1-12, 2021.DOI
10.1038/s41420-021-00428-wISSN
2058-7716Notes
Correction: SARS-CoV-2 engages inflammasome and pyroptosis in human primary monocytes.Você pode encontrar a referida correção do artigo neste link: https://www.nature.com/articles/s41420-021-00477-1
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