| Author | Naik, Shilpa | |
| Author | Alexander, Mallika | |
| Author | Kumar, Pavan | |
| Author | Kulkarni, Vandana | |
| Author | Deshpande, Prasad | |
| Author | Yadana, Su | |
| Author | Leu, Cheng-Shiun | |
| Author | Pereira, Mariana Araújo | |
| Author | Andrade, Bruno de Bezerril | |
| Author | Bhosale, Ramesh | |
| Author | Babu, Subash | |
| Author | Gupta, Amita | |
| Author | Mathad, Jyoti S | |
| Author | Shivakoti, Rupak | |
| Access date | 2021-03-11T12:58:35Z | |
| Available date | 2021-03-11T12:58:35Z | |
| Document date | 2020 | |
| Citation | NAIK, Shilpa et al. Systemic Inflammation in Pregnant Women with Latent Tuberculosis Infection. Frontiers in Immunology, 2020. | |
| URI | https://www.arca.fiocruz.br/handle/icict/46334 | |
| Sponsorship | United States National Institutes of Health, NIH, Bethesda, MD, USA (R00HD089753 to RS and R01HD081929 to AG). JSM received support from NIAID (K23AI129854). Additional support for this work was the NIH-funded Johns Hopkins Baltimore-Washington-India Clinical Trials Unit for NIAID Networks (U01AI069465 to AG). BBA is a senior investigator from the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Brazil. MAP received a research fellowship from the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES; finance code 001). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. | |
| Language | eng | en_US |
| Publisher | Frontiers Media | |
| Rights | open access | |
| Subject in Portuguese | Tuberculose latente | pt_BR |
| Subject in Portuguese | Terceiro Trimestre da Gravidez | pt_BR |
| Subject in Portuguese | Inflamação | pt_BR |
| Subject in Portuguese | Gestantes | pt_BR |
| Subject in Portuguese | Citocinas | pt_BR |
| Title | Systemic Inflammation in Pregnant Women with 2 Latent Tuberculosis Infection | en_US |
| Type | Preprint | |
| Abstract | Recent studies in adults have characterized differences in systemic inflammation between adults with and without latent tuberculosis infection (LTBI+ vs. LTBI-). Potential differences in systemic inflammation by LTBI status has not been assess in pregnant women. Methods: We conducted a cohort study of 155 LTBI+ and 65 LTBI- pregnant women, stratified by HIV status, attending an antenatal clinic in Pune, India. LTBI status was assessed by interferon gamma release assay. Plasma was used to measure systemic inflammation markers using immunoassays: IFNβ, CRP, AGP, I-FABP, IFNγ, IL-1β, soluble CD14 (sCD14), sCD163, TNF, IL-6, IL-17a and IL-13. Linear regression models were fit to test the association of LTBI status with each inflammation marker. We also conducted an exploratory analysis using logistic regression to test the association of inflammatory markers with TB progression. Results: Study population was a median age of 23 (Interquartile range: 21-27), 28% undernourished (mid-upper arm circumference (MUAC) <23 cm), 12% were vegetarian, 10% with gestational diabetes and 32% with HIV. In multivariable models, LTBI+ women had significantly lower levels of third trimester AGP, IL1β, sCD163, IL-6 and IL-17a. Interestingly, in exploratory analysis, LTBI+ TB progressors had significantly higher levels of IL1β, IL-6 and IL-13 in multivariable models compared to LTBI+ non-progressors. Conclusions: Our data shows a distinct systemic immune profile in LTBI+ pregnant women compared to LTBI- women. Data from our exploratory analysis suggest that LTBI+ TB progressors do not have this immune profile, suggesting negative association of this profile with TB progression. | en_US |
| Affilliation | Johns Hopkins University Clinical Research. Byramjee-Jeejeebhoy Government Medical college. Pune, India / Byramjee Jeejeebhoy Government Medical College, Pune, India. | |
| Affilliation | Johns Hopkins University Clinical Research. Byramjee-Jeejeebhoy Government Medical college. Pune, India. | |
| Affilliation | International Centers for Excellence in Research. Pune, India. | |
| Affilliation | Johns Hopkins University Clinical Research. Byramjee-Jeejeebhoy Government Medical college. Pune, India. | |
| Affilliation | Johns Hopkins University Clinical Research. Byramjee-Jeejeebhoy Government Medical college. Pune, India. | |
| Affilliation | Columbia University Mailman School of Public Health. Department of Epidemiology. New York, USA. | |
| Affilliation | Columbia University Mailman School of Public Health. Department of Epidemiology. New York, USA. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil / Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil / Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil. / Faculdade de Tecnologia e Ciências. Curso de Medicina. Salvador, BA, Brasil / Universidade Salvador. Laureate Universities. Salvador, BA, Brasil /Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil. | |
| Affilliation | ohns Hopkins University Clinical Research. Byramjee-Jeejeebhoy Government Medical college. Pune, India / Byramjee Jeejeebhoy Government Medical College, Pune, India. | |
| Affilliation | International Centers for Excellence in Research. Pune, India. | |
| Affilliation | Johns Hopkins University Clinical Research. Byramjee-Jeejeebhoy Government Medical college. Pune, India / Johns Hopkins University School.of Medicine, Department of Medicine. Baltimore, USA. | |
| Affilliation | Weill Cornell Medical College. Department of Medicine. New York, USA. | |
| Affilliation | Columbia University Mailman School of Public Health. Department of Epidemiology. New York, USA. | |
| Subject | Latent TB infection | en_US |
| Subject | TB disease | en_US |
| Subject | Inflammation | en_US |
| Subject | Pregnancy | en_US |
| Subject | Cytokines | en_US |
