Title:	Inclusion Complexes of Non-Steroidal Anti-Inflammatory Drugs with Cyclodextrins: A Systematic Review
Authors:	Miranda, Gustavo Marinho Santos, Vitória Ohana Ramos e Bessa, Jonatas Reis Teles, Yanna C. F. Yahouédéhou, Setondji Cocou Modeste Alexandre Goncalves, Marilda de Souza Ribeiro Filho, Jaime
Affilliation:	Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Investigação em Genética e Hematologia Translacional, Salvador, BA, Brasil. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Investigação em Genética e Hematologia Translacional, Salvador, BA, Brasil. Federal University of Bahia. Institute of Psychology. Salvador, BA, Brazil. Federal University of Paraiba. Agrarian Sciences Center. Department of Chemistry and Physics. Areia, PB, Brazil. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Investigação em Genética e Hematologia Translacional, Salvador, BA, Brasil. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Investigação em Genética e Hematologia Translacional, Salvador, BA, Brasil. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Investigação em Genética e Hematologia Translacional, Salvador, BA, Brasil.
Abstract:	Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most widely used classes of medicines in the treatment of inflammation, fever, and pain. However, evidence has demonstrated that these drugs can induce significant toxicity. In the search for innovative strategies to overcome NSAID-related problems, the incorporation of drugs into cyclodextrins (CDs) has demonstrated promising results. This study aims to review the impact of cyclodextrin incorporation on the biopharmaceutical and pharmacological properties of non-steroidal anti-inflammatory drugs. A systematic search for papers published between 2010 and 2020 was carried out using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol and the following search terms: “Complexation”; AND “Cyclodextrin”; AND “non-steroidal anti-inflammatory drug”. A total of 24 different NSAIDs, 12 types of CDs, and 60 distinct inclusion complexes were identified, with meloxicam and -CD appearing in most studies. The results of the present review suggest that CDs are drug delivery systems capable of improving the pharmacological and biopharmaceutical properties of non-steroidal anti-inflammatory drugs.
Keywords:	Cyclodextrins Non-steroidal anti-inflammatory drugs Inclusion complexes
keywords:	Ciclodextrinas Anti-Inflamatórios não Esteroides Revisão sistemática Preparações Farmacêuticas
Issue Date:	2021
Publisher:	MDPI
Citation:	MIRANDA, Gustavo Marinho et al. Inclusion Complexes of Non-Steroidal Anti-Inflammatory Drugs with Cyclodextrins: A Systematic Review. Biomolecules, v. 11, 2021.
DOI:	10.3390/biom11030361
ISSN:	2218-273X
Copyright:	open access
Appears in Collections:	BA - IGM - Artigos de Periódicos

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